4375-07-9

• 常用中文名：(-)-Epipodophyllotoxin
• 常用英文名：Epipodophyllotoxin
• CAS号：4375-07-9
• 分子式：C₂₂H₂₂O₈
• 分子量：414.40500
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2016-11-11 23:53:59
• 更新时间：2026-08-29 20:12:42
• (-)-Epipodophyllotoxin 是一种从 Podophyllum peltatum 中分离的癌细胞抗增殖剂,在 HeLa 细胞和 MCF-7 细胞中的 GI50 值分别为 0.36 和 0.24 μM。(-)-Epipodophyllotoxin 可在体外抑制有丝分裂纺锤体组装。

名称

• 中文名: 表鬼臼毒素
• 英文名: (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
• 中文别名: (-)-ipodophyllotoxin #天然产物 HY-N7654; 表鬼臼毒素对照品; 表鬼臼毒素标准品; (5R,5,8,9S)-9-羟基-5-(3,4,5-三甲氧基苯基)-5,8,8a,9-四氢呋喃并[3',4':6,7]萘并[2,3-d][1,3]二氧戊环-6(5aH)-酮; (5R,5,8,9S)-9-羟基-5-(3,4,5-三甲氧基苯基)-5,8,8A,9-四氢呋喃并[3',4':6,7]萘并[2,3-D][1,3]二氧戊环-6(5AH)-酮; (-)-蛋白参毒素
• 英文别名: (5R,5,8,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Galloepicatechin; epigallocatechol; Sunphenon EGC; (5R)-5β-(3,4,5-Trimethoxyphenyl)-7α-(hydroxymethyl)-8α-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6β-cboxylic acid 6,7-lactone; (5S,5,8,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-benzofuro[5,6-f][1,3]benzodioxol-8-one; ipodophyllotoxin; (-)-ipodophyllotoxin; (5R)-5,8,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-(5aαH)-one; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5,8,9S); (5R)-5,5aα,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one; Podophyllotoxin 9-imer; ipodophyllotoxin,spindle,antiproliferative,Apoptosis,American,904166,cancer,mayapple,mitotic,Podophyllum peltatum,ipodophyllotoxin,assembly,Inhibitor,inhibit; Teacatechin II; (5S,5,8,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one; EPIGALLOCATECHIN; Greenteacatechins; (5R,5,8,9S)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)-9-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; Eipodophyllotoxin; epi

物化性质

• 密度: 1.37g/cm3
• 沸点: 597.9ºC at 760 mmHg
• 熔点: 160.3 °C
• 分子式: C₂₂H₂₂O₈
• 分子量: 414.40500
• 闪点: 210.2ºC
• 精确质量: 414.13100
• PSA: 92.68000
• LogP: 2.40920
• 外观性状: 白色或类白色结晶粉末
• 折射率: 1.605
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: (-)-Epipodophyllotoxin 是一种从 Podophyllum peltatum 中分离的癌细胞抗增殖剂,在 HeLa 细胞和 MCF-7 细胞中的 GI50 值分别为 0.36 和 0.24 μM。(-)-Epipodophyllotoxin 可在体外抑制有丝分裂纺锤体组装。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Magedov IV, et, al. Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012 Oct 28; 48(84): 10416-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LV2520000 CAS REGISTRY NUMBER : 4375-07-9 BEILSTEIN REFERENCE NO. : 0099162 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C22-H22-O8 MOLECULAR WEIGHT : 414.44 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 135 mg/kg SEX/DURATION : female 25 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 20 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,512,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5374 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 214 (estimated) No. of Female Employees: 214 (estimated)

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