65678-07-1

• 常用中文名：AG1024
• 常用英文名：AG-1024
• CAS号：65678-07-1
• 分子式：C₁₄H₁₃BrN₂O
• 分子量：305.170
• 相关类别： 生物化工 抑制剂 蛋白酪氨酸激酶
• 发布时间：2017-07-25 10:43:34
• 更新时间：2025-08-20 10:44:12
• AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化,IC50为7 μM,而对IR的IC50则为57 μM。

名称

• 中文名: 2-[[3-溴-5-叔丁基-4-羟基苯基]亚甲基]丙二腈
• 英文名: 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
• 英文别名: (3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile; 3-bromo-5-t-butyl-4-hydroxy-benzylidene-malononitrile; propanedinitrile, [[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-; 3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile; 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile; [3-Bromo-4-hydroxy-5-(2-methyl-2-propanyl)benzylidene]malononitrile; 2-[(3-bromo-4-hydroxy-5-tert-butyl-phenyl)methylidene]propanedinitrile; Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-; Tyrphostin AG 1024; ag1024; propanedinitrile,[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]; AG-1024

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 379.8±42.0 °C at 760 mmHg
• 分子式: C₁₄H₁₃BrN₂O
• 分子量: 305.170
• 闪点: 183.5±27.9 °C
• 精确质量: 304.021118
• PSA: 67.81000
• LogP: 4.18
• 外观性状: solid | yellow
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.609
• 储存条件: −20°C
• 水溶解性: DMSO: soluble

生物活性

• 描述: AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化,IC50为7 μM,而对IR的IC50则为57 μM。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 蛋白酪氨酸激酶 >> IGF-1R
  研究领域 >> 癌症
• 参考文献:

  [1]. Párrizas M, et al. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33.

  [2]. Wen B, et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer. 2001 Dec 14;85(12):2017-21.

  [3]. von Willebrand M, et al. The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells. Cancer Res. 2003 Mar 15;63(6):1420-9.

  [4]. Deutsch E, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. Br J Cancer. 2004 Nov 1;91(9):1735-41.

安全

• 安全声明 (欧洲): 22-24/25
• WGK德国: 3
• 海关编码: 2926909090

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海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%