79952-42-4

• 常用中文名：辛伐他汀内酯二醇
• 常用英文名：Lovastatin Diol Lactone
• CAS号：79952-42-4
• 分子式：C₁₉H₂₈O₄
• 分子量：320.423
• 相关类别： 信号通路 代谢酶/蛋白酶 HMG-CoA还原酶(HMGCR)
• 发布时间：2018-08-03 00:07:20
• 更新时间：2026-06-30 23:28:48
• Monacolin J 是胆固醇合成抑制剂,能够抑制 HMG-CoA reductase 的活性。

名称

• 中文名: 莫那可林J
• 英文名: monacolin J
• 中文别名: 洛伐他汀二醇内酯; 辛伐他汀内酯二醇,10 MM DMSO 溶液; 辛伐他汀杂质H; 洛伐他汀酮内酯; 洛伐他汀二醇内酯 ((4R,6R)-6-[2-[(1S,2S,6R,8S,8-1,2,6,7,8,8A-六氢-8-羟基-2,6-二甲基-1-萘基]乙基]四氢-4-羟基-2H-吡喃-2-酮); 洛伐他汀杂质14; 6(R)-[2-(8(S)-羟基]-2(S),6(R)-二甲基-1,2,6,7,8,8A(R)-六氢-1(S)-萘基]乙基-4(R)-羟基-3,4,5,6-四氢-2H-吡喃-2-酮; 辛伐他汀杂质10; 洛伐他汀杂质8; 辛伐他汀杂质H(4R-异构体); 洛伐他汀内酯二醇; 辛伐他汀杂质08; 辛伐他汀杂质
• 英文别名: SiMvastatin Lactone Diol; Simvastatin Impurity H; Monacolin J; Simvastatin Impurity H (4R)-Diastereomer; SimvastatinimpH; Simvastatin Impurity H (Simvastatin Lactone Diol/ Lovastatin Lactone Diol); Lovastatin Lactone Diol; (4RS,6R)-4-Hydroxy-6-[2-[(1S,2S,6R,8S,8-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8ahexahydronaphthalen-1-yl]ethyl]tetrahydro-2H-pyran-2-one; Lovastatin Diol Lactone ((4R,6R)-6-[2-[(1S,2S,6R,8S,8-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimeth; Simvastatin Impurity H (4R-Isomer); Lovastatin diol lactone; Simvastatin Impurity 8; Lovastatin Diol Lactone ((4R,6R)-6-[2-[(1S,2S,6R,8S,8-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one); Lovastatin Lactone Diol (Simvastatin Impurity H/ Simvastatin Lactone Diol); Antibiotic MB 530A; Autophagy,inhibit,Inhibitor,Monacolin J,HMG-CoA Reductase (HMR); (4R,6R)-4-Hydroxy-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]ethyl}tetrahydro-2H-pyran-2-one; (4R,6R); 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one; Monacolin J, 10 mM in DMSO; 2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R); (4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one; Lovastatin Impurity 8; (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one; Simvastatin EP Impurity H

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 535.7±50.0 °C at 760 mmHg
• 熔点: 104-114 °C
• 分子式: C₁₉H₂₈O₄
• 分子量: 320.423
• 闪点: 191.2±23.6 °C
• 精确质量: 320.198761
• PSA: 66.76000
• LogP: 1.81
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.558
• 储存条件: -20°C，干燥，密封

生物活性

• 描述: Monacolin J 是胆固醇合成抑制剂,能够抑制 HMG-CoA reductase 的活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 代谢疾病
• 靶点:

  HMG-CoA reductase[1]

• 体外研究: Monacolin J是胆固醇生物合成的抑制剂,并抑制HMG-CoA还原酶的活性。 Monacolin J的Na盐在1.2μg/ mL时对还原酶产生50％的抑制[1]。
• 参考文献:

  [1]. Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2.

安全

• 危害码 (欧洲): Xi