Lovastatin Diol Lactone

Modify Date: 2024-01-03 11:19:00

Lovastatin Diol Lactone Structure
Lovastatin Diol Lactone structure
Common Name Lovastatin Diol Lactone
CAS Number 79952-42-4 Molecular Weight 320.423
Density 1.2±0.1 g/cm3 Boiling Point 535.7±50.0 °C at 760 mmHg
Molecular Formula C19H28O4 Melting Point 104-114 °C
MSDS N/A Flash Point 191.2±23.6 °C

 Use of Lovastatin Diol Lactone


Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

 Names

Name monacolin J
Synonym More Synonyms

 Lovastatin Diol Lactone Biological Activity

Description Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
Related Catalog
Target

HMG-CoA reductase[1]

In Vitro Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL[1].
References

[1]. Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 535.7±50.0 °C at 760 mmHg
Melting Point 104-114 °C
Molecular Formula C19H28O4
Molecular Weight 320.423
Flash Point 191.2±23.6 °C
Exact Mass 320.198761
PSA 66.76000
LogP 1.81
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.558

 Safety Information

Hazard Codes Xi

 Synonyms

Antibiotic MB 530A
(4R,6R)-4-Hydroxy-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]ethyl}tetrahydro-2H-pyran-2-one
2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)-
Monacolin J
(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one
Lovastatin diol lactone
Simvastatin EP Impurity H