24365-47-7

• 常用中文名：亮抑酶肽
• 常用英文名：leupeptin
• CAS号：24365-47-7
• 分子式：C₂₀H₃₈N₆O₄
• 分子量：426.55400
• 相关类别： 研究领域 癌症
• 发布时间：2018-09-23 13:53:59
• 更新时间：2024-01-11 18:28:16
• Leupptin Ac-LL是一种放线菌蛋白酶抑制剂。亮蛋白肽Ac LL具有抗血浆活性[1]。

名称

• 中文名: 亮抑酶酞
• 英文名: leupeptin
• 中文别名: 亮肽素
• 英文别名: acetyl-Leu-Leu-Arg-al; 2-Methyl-5-oxotetrahydro-2-furanyl acetate; Acetyllaevulinsaeure; 5-acetoxy-5-methyl-dihydro-furan-2-one; Ac-Leu-Leu-Arg-H; N-acetyl-Leu-Leu-argininal

物化性质

• 密度: 1.21g/cm3
• 分子式: C₂₀H₃₈N₆O₄
• 分子量: 426.55400
• 精确质量: 426.29500
• PSA: 166.27000
• LogP: 2.37870
• 折射率: 1.557

生物活性

• 描述: Leupptin Ac-LL是一种放线菌蛋白酶抑制剂。亮蛋白肽Ac LL具有抗血浆活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YV4205000 CHEMICAL NAME : Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guan idinobutyl)-4-methyl- CAS REGISTRY NUMBER : 24365-47-7 LAST UPDATED : 198510 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C20-H38-N6-O4 MOLECULAR WEIGHT : 426.64 WISWESSER LINE NOTATION : MUYZM3YVHMVY1Y1&1&MVYMV1&1Y1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 720 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 740 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 74 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

合成路线

45314-99-6 ~% 24365-47-7

文献：Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325

2018-66-8 ~% 24365-47-7

文献：Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325

61-90-5 ~% 24365-47-7

文献：Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325

81944-83-4 ~% 24365-47-7

文献：Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325

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