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24365-47-7

24365-47-7 structure
24365-47-7 structure
  • Name: leupeptin
  • Chemical Name: leupeptin
  • CAS Number: 24365-47-7
  • Molecular Formula: C20H38N6O4
  • Molecular Weight: 426.55400
  • Catalog: Research Areas Cancer
  • Create Date: 2018-09-23 13:53:59
  • Modify Date: 2025-08-25 19:27:54
  • Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity[1].
Name leupeptin
Synonyms acetyl-Leu-Leu-Arg-al
2-Methyl-5-oxotetrahydro-2-furanyl acetate
Acetyllaevulinsaeure
5-acetoxy-5-methyl-dihydro-furan-2-one
Ac-Leu-Leu-Arg-H
N-acetyl-Leu-Leu-argininal
Description Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity[1].
Related Catalog
Density 1.21g/cm3
Molecular Formula C20H38N6O4
Molecular Weight 426.55400
Exact Mass 426.29500
PSA 166.27000
LogP 2.37870
Index of Refraction 1.557

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV4205000
CHEMICAL NAME :
Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guan idinobutyl)-4-methyl-
CAS REGISTRY NUMBER :
24365-47-7
LAST UPDATED :
198510
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H38-N6-O4
MOLECULAR WEIGHT :
426.64
WISWESSER LINE NOTATION :
MUYZM3YVHMVY1Y1&1&MVYMV1&1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
740 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
74 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977
45314-99-6 structure

45314-99-6

~%

24365-47-7 structure

24365-47-7

Literature: Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325
2018-66-8 structure

2018-66-8

~%

24365-47-7 structure

24365-47-7

Literature: Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325
61-90-5 structure

61-90-5

~%

24365-47-7 structure

24365-47-7

Literature: Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325
81944-83-4 structure

81944-83-4

~%

24365-47-7 structure

24365-47-7

Literature: Saino; Someno; Miyazaki; Ishii Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325
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