1165923-92-1

• 常用中文名：6-氰基-5-甲基-3,4-二氢异喹啉-2(1h)-羧酸叔丁酯
• 常用英文名：tert-butyl 6-cyano-5-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
• CAS号：1165923-92-1
• 分子式：C₁₆H₂₀N₂O₂
• 分子量：272.34200
• 发布时间：2018-12-18 17:12:49
• 更新时间：2024-01-09 21:25:41

名称

• 中文名: 6-氰基-5-甲基-3,4-二氢异喹啉-2(1h)-羧酸叔丁酯
• 英文名: tert-butyl 6-cyano-5-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylate

物化性质

• 分子式: C₁₆H₂₀N₂O₂
• 分子量: 272.34200
• 精确质量: 272.15200
• PSA: 53.33000
• LogP: 3.09778

安全

• 海关编码: 2933499090

合成路线

557-21-1 1165923-91-0 ~89% 1165923-92-1

文献：Demont, Emmanuel H.; Arpino, Sandra; Bit, Rino A.; Campbell, Colin A.; Deeks, Nigel; Desai, Sapna; Dowell, Simon J.; Gaskin, Pam; Gray, James R. J.; Harrison, Lee A.; Haynes, Andrea; Heightman, Tom D.; Holmes, Duncan S.; Humphreys, Philip G.; Kumar, Umesh; Morse, Mary A.; Osborne, Greg J.; Panchal, Terry; Philpott, Karen L.; Taylor, Simon; Watson, Robert; Willis, Robert; Witherington, Jason Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6724 - 6733

1165923-91-0 557-21-1 ~% 1165923-92-1

文献：GLAXO GROUP LIMITED Patent: WO2009/80724 A1, 2009 ; Location in patent: Page/Page column 29 ; WO 2009/080724 A1

79099-07-3 ~% 1165923-92-1

文献：GLAXO GROUP LIMITED; BAILEY, James, Matthew; BIT, Rino, Antonio; DEMONT, Emmanuel, Hubert; HARRISON, Lee, Andrew; JONES, Katherine, Louise; SMETHURST, Christian, Alan, Paul; WITHERINGTON, Jason Patent: WO2010/146105 A1, 2010 ; WO 2010/146105 A1

1258440-70-8 ~% 1165923-92-1

文献：GLAXO GROUP LIMITED; BAILEY, James, Matthew; BIT, Rino, Antonio; DEMONT, Emmanuel, Hubert; HARRISON, Lee, Andrew; JONES, Katherine, Louise; SMETHURST, Christian, Alan, Paul; WITHERINGTON, Jason Patent: WO2010/146105 A1, 2010 ; WO 2010/146105 A1

1165923-89-6 ~% 1165923-92-1

文献：GLAXO GROUP LIMITED; BAILEY, James, Matthew; BIT, Rino, Antonio; DEMONT, Emmanuel, Hubert; HARRISON, Lee, Andrew; JONES, Katherine, Louise; SMETHURST, Christian, Alan, Paul; WITHERINGTON, Jason Patent: WO2010/146105 A1, 2010 ; WO 2010/146105 A1

207691-65-4 ~% 1165923-92-1

文献：GLAXO GROUP LIMITED; BAILEY, James, Matthew; BIT, Rino, Antonio; DEMONT, Emmanuel, Hubert; HARRISON, Lee, Andrew; JONES, Katherine, Louise; SMETHURST, Christian, Alan, Paul; WITHERINGTON, Jason Patent: WO2010/146105 A1, 2010 ; WO 2010/146105 A1

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%