25696-60-0

25696-60-0结构式

常用中文名：牛磺酸β-鼠胆酸钠盐
常用英文名：Tauro-β-muricholic acid
CAS号：25696-60-0
分子式：C₂₆H₄₅NO₇S
分子量：515.70300
相关类别：信号通路细胞凋亡细胞凋亡
发布时间：2017-06-15 12:21:06
更新时间：2026-07-03 20:14:07
Tauro-β-muricholic acid (TβMCA) 是一种三羟基化胆汁酸。Tauro-β-muricholic acid 是一种竞争性、可逆的 FXR 拮抗剂 (IC50 = 40 μM)。Tauro-β-muricholic Acid 具有抗细胞凋亡作用。Tauro-β-muricholic acid 通过维持线粒体膜电位抑制胆汁酸诱导的肝细胞凋亡 (apoptosis)。

中文名	牛磺酸β-鼠胆酸钠盐
英文名	tauroβ-muricholic acid
中文别名	牛磺-B-鼠胆酸牛磺酸-Β-巯基乙酸-D4钠盐牛磺-B霉素酸 Β-牛磺尿酸牛磺-Β-鼠胆酸钠-[D4] 牛磺-Β-鼠胆酸
英文别名	2-((4R)-4-((3R,5R,6S,7R,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid Tauro-β-muricholic Acid Tauro-b-muricholic acid beta-Tauromuricholic Acid 5β-CHOLANIC ACID-3α, 6β, 7β, -TRIOL N-(2-SULPHOETHYL)-AMIDE SODIUM SALT tauro-beta-muricholic acid tauromuricholic acid 2-[(3α,6β,7β-Trihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid Ethanesulfonic acid, 2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino] Tauro-Beta-muricholic Acid Tauro-β-muricholate 2-[[(4R)-4-[(3R,5R,6S,7R,10R,13R,17R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid

描述	Tauro-β-muricholic acid (TβMCA) 是一种三羟基化胆汁酸。Tauro-β-muricholic acid 是一种竞争性、可逆的 FXR 拮抗剂 (IC50 = 40 μM)。Tauro-β-muricholic Acid 具有抗细胞凋亡作用。Tauro-β-muricholic acid 通过维持线粒体膜电位抑制胆汁酸诱导的肝细胞凋亡 (apoptosis)。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> FXR 研究领域 >> 代谢疾病
靶点	40 μM (FXR)[1]
参考文献	[1]. Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012 Aug 10;424(4):758-64. [2]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35.