306935-14-8

• 常用中文名：3-苯基-5-哌嗪基-1,2,4-噻二唑
• 常用英文名：3-PHENYL-5-PIPERAZINO-1,2,4-THIADIAZOLE
• CAS号：306935-14-8
• 分子式：C₁₂H₁₄N₄S
• 分子量：246.33100
• 发布时间：2018-12-24 18:20:58
• 更新时间：2024-01-15 16:15:35
• 下载msds

名称

• 中文名: 3-苯基-5-哌嗪基-1,2,4-噻二唑
• 英文名: 3-phenyl-5-piperazin-1-yl-1,2,4-thiadiazole
• 中文别名: 3-苯基-5-哌嗪-1,2,4-噻二唑
• 英文别名: 3-Phenyl-5-piperazino-1,2,4-thiadiazole; 3-phenyl-5-(piperazin-1-yl)-1,2,4-thiadiazole; 1-(3-Phenyl-1,2,4-thiadiazol-5-yl)piperazine

物化性质

• 密度: 1.238g/cm3
• 沸点: 415.9ºC at 760mmHg
• 熔点: 91-93ºC
• 分子式: C₁₂H₁₄N₄S
• 分子量: 246.33100
• 闪点: 205.3ºC
• 精确质量: 246.09400
• PSA: 69.29000
• LogP: 2.00850
• 折射率: 1.609

MSDS

Name: 3-Phenyl-5-piperazino-1 2 4-thiadiazole 97% Material Safety Data Sheet Synonym: CAS: 306935-14-8 Section 1 - Chemical Product MSDS Name:3-Phenyl-5-piperazino-1 2 4-thiadiazole 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 306935-14-8 3-Phenyl-5-piperazino-1,2,4-thiadiazol 97% unlisted Hazard Symbols: C Risk Phrases: 34 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Causes burns.Air sensitive. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. Ingestion: Causes gastrointestinal tract burns. Inhalation: Causes chemical burns to the respiratory tract. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under nitrogen. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 306935-14-8: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 91 - 93 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H14N4S Molecular Weight: 246 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents, acids, acid chlorides, halogens, halogenated agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 306935-14-8 unlisted. LD50/LC50: Not available. Carcinogenicity: 3-Phenyl-5-piperazino-1,2,4-thiadiazole - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S.* Hazard Class: 8 UN Number: 3259 Packing Group: III IMO Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S. Hazard Class: 8 UN Number: 3259 Packing Group: III RID/ADR Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S. Hazard Class: 8 UN Number: 3259 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 306935-14-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 306935-14-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 306935-14-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): C: Corrosive;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36/37/39
• 海关编码: 2934999090

合成路线

887623-99-6 ~98% 306935-14-8

文献：Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41

110-85-0 1670-14-0 ~% 306935-14-8

文献：US2007/4741 A1, ; Page/Page column 13 ;

110-85-0 1670-14-0 594-42-3 ~49% 306935-14-8

文献：Keith, John M.; Apodaca, Richard; Xiao, Wei; Seierstad, Mark; Pattabiraman, Kanaka; Wu, Jiejun; Webb, Michael; Karbarz, Mark J.; Brown, Sean; Wilson, Sandy; Scott, Brian; Tham, Chui-Se; Luo, Lin; Palmer, James; Wennerholm, Michelle; Chaplan, Sandra; Breitenbucher, J. Guy Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4838 - 4843

24255-23-0 ~% 306935-14-8

文献：Bioorganic and Medicinal Chemistry, , vol. 21, # 1 p. 28 - 41

1670-14-0 ~% 306935-14-8

文献：Bioorganic and Medicinal Chemistry, , vol. 21, # 1 p. 28 - 41

上下游产品

上游产品  4
110-85-0 1670-14-0 594-42-3 24255-23-0
下游产品  1
681136-29-8

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%