4360-12-7

• 常用中文名：阿马灵，阿义马林
• 常用英文名：Ajmaline
• CAS号：4360-12-7
• 分子式：C₂₀H₂₆N₂O₂
• 分子量：326.43300
• 相关类别： 原料药 循环系统用药 抗心律失常药
• 发布时间：2018-07-04 17:24:42
• 更新时间：2026-07-01 16:51:14
• Ajmaline是一种生物碱, 是一种Ia类的抗心律失常药。

名称

• 中文名: 阿义马林
• 英文名: ajmaline
• 中文别名: 阿义马林,10 MM DMSO 溶液; 阿义吗啉; 阿马灵,阿义马林; 阿义吗啉 降血压药物; 阿嗎靈鹼; 阿吗灵; (5,6S,8R,9S,10R,11R,11AS,12,13R)-9-乙基-5-甲基-5A,6,8,9,10,11,11A,12-八氢-5H-6,10:11,12A-二甲桥吲哚并[3,2-B]喹啉-8,13-二醇; 蘿芙鹼; 萝芙木碱(阿马林); 阿马林; 阿马灵; 阿义马林/阿马林/阿马义林/阿义吗啉; 阿马林(阿义吗啉); 缓脉灵; 阿义马林 阿马林 西萝芙木碱; 西萝芙木碱; 阿义吗啉/阿马林
• 英文别名: Cartagine; Ajmalan-17,20-diol; Ajmaline, 10 mM in DMSO; Takycor; 21-diol,(17r,21-alpha)-ajmalan-1; AJMALAN-17,21-DIOL,(17R,21); Ajmaline (6CI, 7CI, 8CI); Tajmalin; Ajmalin; AJMALINE:AJMALAN-17,21-DIOL,(17R,21); AJMALINE(P); Ajamline Fr P; Cisoprodol Impurity 10; 5H-6,10:11,12a-Dimethanoindolo[3,2-b]quinolizine, ajmalan-17,21-diol deriv; (17R,21α-AjMalan-17,21-diol; Ritmos; Rytmalin; Cdiorythmine; Ajmalan-17,21-diol, (17R,21α); AJMALINE; Ignazin; Ajmalan-17,21-diol; Raugalline; Rauwolfin; Merabitol; (5,6S,8R,9S,10R,11R,11aS,12,13R)-9-Ethyl-5-methyl-5a,6,8,9,10,11,11a,12-octahydro-5H-6,10:11,12a-dimethanoindolo[3,2-b]quinolizine-8,13-diol; AJMALINE //BP; RAUWOLFINE; Ajmalan-17,21-diol, (17R,21alpha); Ctagine; Takhmalin; Siddiqui; Takycor Azapromazine; itmina; Gilurytmal; Rhytmaton; AJMALINE(RG); Tachmalin; Aritmina

物化性质

• 密度: 1.373g/cm3
• 沸点: 519.406ºC at 760 mmHg
• 熔点: 189ºC
• 分子式: C₂₀H₂₆N₂O₂
• 分子量: 326.43300
• 闪点: 285.155ºC
• 精确质量: 326.19900
• PSA: 46.94000
• LogP: 1.55740
• 外观性状: 白色固体
• 折射率: 1.701
• 储存条件: -20℃
• 分子结构:

  1、摩尔折射率：92.02

  2、摩尔体积（cm³/mol）：237.8

  3、等张比容（90.2K）：682

  4、表面张力（dyne/cm）：67.6

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：36.48

  7、单一同位素质量：326.199428Da

  8、标称质量：326Da

  9、平均质量：326.4326Da

• 计算化学:

  1、疏水参数计算参考值（XlogP）：1.8

  2、氢键供体数量：2

  3、氢键受体数量：4

  4、可旋转化学键数量：1

  5、互变异构体数量：无

  6、拓扑分子极性表面积（TPSA）：46.9

  7、重原子数量：24

  8、表面电荷：0

  9、复杂度：570

  10、同位素原子数量：0

  11、确定原子立构中心数量：8

  12、不确定原子立构中心数量：1

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：1

• 更多:

  1. 性状：淡琥珀色四角形结晶。无气味。味苦。

  2. 密度（g/mL,25/4℃）： 未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：205-207

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º，C=0.4，氯仿中）：+131

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于甲醇、乙醇、乙醚和氯仿，微溶于水。

生物活性

• 描述: Ajmaline是一种生物碱, 是一种Ia类的抗心律失常药。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 心血管疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AX8050000 CHEMICAL NAME : Ajmaline CAS REGISTRY NUMBER : 4360-12-7 LAST UPDATED : 199201 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C20-H26-N2-O2 MOLECULAR WEIGHT : 326.48 WISWESSER LINE NOTATION : T5 F6 E56 B6 B6/CR/NS A 5BBCEO S EX LN ONT&TTTTJ DQ L1 PQ Q2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,39,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 94 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 21,331,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 216 mg/kg TOXIC EFFECTS : Cardiac - change in rate REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,865,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 26 mg/kg TOXIC EFFECTS : Cardiac - other changes REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,36,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 255 mg/kg TOXIC EFFECTS : Cardiac - change in rate REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,865,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Cardiac - change in rate REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,865,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 8,188,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 21,331,1987 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Cardiac - change in rate REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,865,1964 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : 316 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 178 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 25-20/21/22
• 安全声明 (欧洲): 13-45-36
• 危险品运输编码: UN 1544
• RTECS号: AX8050000
• 包装等级: III
• 危险类别: 6.1(b)