357400-13-6

• 常用中文名：NNC 55-0396
• 常用英文名：NNC 55-0396
• CAS号：357400-13-6
• 分子式：C₃₀H₄₀Cl₂FN₃O₂
• 分子量：564.56200
• 相关类别： 信号通路 跨膜转运 钙通道
• 发布时间：2017-01-07 08:49:34
• 更新时间：2024-01-02 13:02:49
• NNC 55-0396是Mibefradil衍生物,是T型钙离子通道阻断剂。

名称

• 中文名: NNC 55-0396
• 英文名: NNC 55-0396 dihydrochloride,(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylcyclopropanecarboxylatedihydrochloride
• 英文别名: nnc 55-0396 dihydrochloride; NNC 55-0396

物化性质

• 沸点: 713.8ºC at 760mmHg
• 分子式: C₃₀H₄₀Cl₂FN₃O₂
• 分子量: 564.56200
• 闪点: 385.5ºC
• 精确质量: 563.24800
• PSA: 58.22000
• LogP: 7.63850
• 储存条件: 2-8℃

生物活性

• 描述: NNC 55-0396是Mibefradil衍生物,是T型钙离子通道阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36.

  [2]. Timo Strünker, Normann Goodwin, Christoph Brenker, et al. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature, 2011,471, 382-386.

  [3]. Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659.

  [4]. Li M, Hansen JB, Huang L, et al. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005 Summer;23(2):173-96.

  [5]. Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.