NNC 55-0396

• 常用名: NNC 55-0396
• 英文名: NNC 55-0396
• CAS号: 357400-13-6
• 分子量: 564.56200
• 密度: N/A
• 沸点: 713.8ºC at 760mmHg
• 分子式: C₃₀H₄₀Cl₂FN₃O₂
• 熔点: N/A
• 闪点: 385.5ºC

NNC 55-0396用途

NNC 55-0396是Mibefradil衍生物,是T型钙离子通道阻断剂。

NNC 55-0396名称

• 中文名: NNC 55-0396
• 英文名: NNC 55-0396 dihydrochloride,(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylcyclopropanecarboxylatedihydrochloride

NNC 55-0396生物活性

• 描述: NNC 55-0396是Mibefradil衍生物,是T型钙离子通道阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36.

  [2]. Timo Strünker, Normann Goodwin, Christoph Brenker, et al. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature, 2011,471, 382-386.

  [3]. Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659.

  [4]. Li M, Hansen JB, Huang L, et al. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005 Summer;23(2):173-96.

  [5]. Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.

NNC 55-0396物理化学性质

• 沸点: 713.8ºC at 760mmHg
• 分子式: C₃₀H₄₀Cl₂FN₃O₂
• 分子量: 564.56200
• 闪点: 385.5ºC
• 精确质量: 563.24800
• PSA: 58.22000
• LogP: 7.63850
• InChIKey: BCCQNBXHUMKLFW-TYTAECQYSA-N
• SMILES: CC(C)C1c2ccc(F)cc2CCC1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C1CC1.Cl.Cl
• 储存条件: 2-8℃

NNC 55-0396靶点实验

查看更多实验

实验名称：Inhibition of Cav2.2 in human SH-SY5Y cells assessed as decrease in KCl-induced calci... 来源：ChEMBL 靶标：Voltage-dependent N-type calcium channel subunit alpha-1B External Id：CHEMBL4223234

实验名称：Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513083

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of recombinant human Cav3.2-alpha1 expressed in HEK293T cells assessed as ... 来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H External Id：CHEMBL4223235

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：LOPAC HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA from hypervirulent Klebsiella pneumoniae External Id：IucA Pilot Assay LOPAC Library

实验名称：Inhibition of human N type calcium channel Cav2.2 endogenously expressed in SH-SY5Y c... 来源：ChEMBL 靶标：Voltage-dependent N-type calcium channel subunit alpha-1B External Id：CHEMBL4729685

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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NNC 55-0396英文别名

• nnc 55-0396 dihydrochloride
• NNC 55-0396