853-34-9

• 常用中文名：酮基保太松
• 常用英文名：Kebuzone
• CAS号：853-34-9
• 分子式：C₁₉H₁₈N₂O₃
• 分子量：322.358
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-07-07 22:38:29
• 更新时间：2024-01-02 18:00:54
• 克布松是一种非甾体抗炎物质,可用于研究血栓静脉炎和类风湿性关节炎等炎性疾病[1]。

名称

• 中文名: 酮基保太松
• 英文名: kebuzone
• 中文别名: 凯布宗; 凯保松
• 英文别名: Chebutan; 4-(3-Oxobutyl)-1,2-diphenylpyrazolidine-3,5-dione; Recheton; Kebuzone; 1,2-Diphenyl-4-(g-ketobutyl)-3,5-pyrazolidinedione; Cetophenylbutazone; ketophenylbutazone; Ketophenylbutazon; Ketazon; Chetazolidin; Copirene; Ketason; 3,5-Pyrazolidinedione, 4-(3-oxobutyl)-1,2-diphenyl-; 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione; Chepirol; Ketazone

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 462.8±37.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈N₂O₃
• 分子量: 322.358
• 闪点: 199.5±18.9 °C
• 精确质量: 322.131744
• PSA: 57.69000
• LogP: 1.25
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.599

生物活性

• 描述: 克布松是一种非甾体抗炎物质,可用于研究血栓静脉炎和类风湿性关节炎等炎性疾病[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ8540000 CHEMICAL NAME : 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(3-oxobutyl)- CAS REGISTRY NUMBER : 853-34-9 BEILSTEIN REFERENCE NO. : 0308507 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C19-H18-N2-O3 MOLECULAR WEIGHT : 322.39 WISWESSER LINE NOTATION : T5VNNV EHJ BR& CR& E2V1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 720 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,229,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 683 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,390,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,229,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 315 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,229,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 22,66,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 662 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,390,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,390,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,390,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,1339,1966

安全

• 海关编码: 2933990090

合成路线

122-66-7 ~% 853-34-9

文献：Cesko-Slovenska Farmacie, , vol. 7, p. 303 Chem.Abstr., , p. 1313

116604-64-9 ~% 853-34-9

文献：Helvetica Chimica Acta, , vol. 40, p. 402,406

7796-23-8 ~% 853-34-9

文献：Helvetica Chimica Acta, , vol. 40, p. 402,406

10561-01-0 ~% 853-34-9

文献：Cesko-Slovenska Farmacie, , vol. 7, p. 303 Chem.Abstr., , p. 1313

10553-86-3 ~% 853-34-9

文献：Cesko-Slovenska Farmacie, , vol. 7, p. 303 Chem.Abstr., , p. 1313

2652-77-9 ~% 853-34-9

文献：Cesko-Slovenska Farmacie, , vol. 7, p. 303 Chem.Abstr., , p. 1313

上下游产品

上游产品  5
122-66-7 7796-23-8 10561-01-0 10553-86-3
2652-77-9
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93371-32-5 93371-33-6 93371-31-4 93371-35-8
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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%