401900-40-1

• 常用中文名：N-[4-硝基-3-(三氟甲基)苯基]-(2S)-3-[4-(乙酰基氨基)苯氧基]-2-羟基-2-甲基丙酰胺
• 常用英文名：Andarine
• CAS号：401900-40-1
• 分子式：C₁₉H₁₈F₃N₃O₆
• 分子量：441.358
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Androgen Receptor 激动剂
• 发布时间：2018-10-19 16:29:14
• 更新时间：2026-07-12 20:16:24
• Andarine (S-4)是选择性雄激素受体调节剂（SARM），还是部分激动剂。

名称

• 中文名: N-[4-硝基-3-(三氟甲基)苯基]-(2S)-3-[4-(乙酰基氨基)苯氧基]-2-羟基-2-甲基丙酰胺
• 英文名: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
• 中文别名: N-[4-硝基-3-(三氟甲基)苯基]-(2S)-3-[4-(乙酰基氨基)苯氧基]-2-羟基-2-甲基丙酰胺(SM S4); (2S)-3-[4-(乙酰氨基)苯氧基]-2-羟基-2-甲基-N-[4-硝基-3-(三氟甲基)苯基]-丙胺; N-[4-硝基-3-(三氟甲基)苯基]; 安娜琳; S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺; 三氟甲基-苯基; ANDINE,激动剂; 安达林-D4; S-3-(4-乙酰氨基苯氧基)-2-羟基-2-甲基-N-(4-硝基-3-三氟甲基苯基)丙酰胺(S4); (2R)-3-(4-氰基苯氧基)-N-[4-氰基-3-(三氟甲基)苯基]-2-羟基-2-甲基丙酰胺
• 英文别名: Anadine; (S)-3-(4-Acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide; S-3-(4-Acetylamino-phenoxy)-2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide; s-4/Andine(Cas number:401-1); (2S)-3-(4-Acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; (1132-5) ostine; hot selling Andine; (2R)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide; Andine,GTX-007/GTX007; Andine(S4),whnohe_lucy(at)163.com; S4 Powder Andine; MK-2866 Andine; MK-2866; (2S)-3-[4-(Acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Phmaceutical ade Andine(S-4); S4 401-1; OSTINE(MK-2866),ENOBOSM; Andine-d4; S4 Powder Andine GTX-007 SM Steroids for Muscle Building,mk-2866,MK-2866; SMS S-4 Andine; Sms mk; Andine, >=; N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide Andine; GTX007; ANDINE;401-1; GTX 007;GTX007;S-4; Andine (GTX-007); sM s4; S1140_Selleck; S4; Ostine/MK-2866 Andine; Sm powder Andine S4 CAS NO.401-1; GTX 007;GTX007; S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide; 3-(4-acetaMidophenoxy)-2-hydroxy-2-Methyl-N-[4-nitro-3-(trifluoroMethyl)phenyl]propanaMide; Andine(S4) whnohe_coline(at)163.com; GTx007; S4 Powder Andine GTX-007 SM Steroids for Muscle Building; ANDINE;GTX-007; S-4; UNII-7UT2HAH49H; Andine MK-2B66; Sm powder Andine S4; GTx007,selective,toxicity,GTx 007,Inhibitor,prostate,low,S 4,tissue,Andine,Androgen Rector,inhibit; Andine(S4); S-4(Andine ); Andine; Andine Purity; N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino; (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; (S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; Manufacturers wholesale Andine S4/S-4 with best price and high quality CAS NO.401-1; Manufacturers Supply best quality Andine 401-1 CAS NO.401-1; Propanamide,3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phe nyl]-,(2S); Andine (S-4) S4 Gtx-007; Ostine S4; Andine (This product is only available in Japan.); Andine //BP; GTx-007; Andine S4 20mg Tablets; (S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide); Ostarine; N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide; S-3-(4-acetaminophenoxy) -2-hydroxy-2-methyl-N -(4-nitro-3-trifluoromethyl phenyl) propionamide; Andine,GTK-007; S4 (Andine)-1 am; Andine S4/GTX-007

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 698.7±55.0 °C at 760 mmHg
• 熔点: 70-74ºC
• 分子式: C₁₉H₁₈F₃N₃O₆
• 分子量: 441.358
• 闪点: 376.4±31.5 °C
• 精确质量: 441.114777
• PSA: 133.48000
• LogP: 4.01
• 外观性状: 淡黄色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.605
• 储存条件: Refrigerator

生物活性

• 描述: Andarine (S-4)是选择性雄激素受体调节剂(SARM),还是部分激动剂。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Thevis M, Geyer H, Kamber M, Sch?nzer W.Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product.Drug Test Anal. 2009 Aug;1(8):387-92.

  [2]. Thevis M, Thomas A, Fussh?ller G, Beuck S, Geyer H, Sch?nzer W.Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes.Rapid Commun Mass Spectrom. 2010 Aug

  [3]. Thomas A, Geyer H, Sch?nzer W, Crone C, Kellmann M, Moehring T, Thevis M.Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer.Anal Bioanal Chem. 2012 May;40

  [4]. Guddat S, Solymos E, Orlovius A, Thomas A, Sigmund G, Geyer H, Thevis M, Sch?nzer W.High-throughput screening for various classes of doping agents using a new 'dilute-and-shoot' liquid chromatography-tandem mass spectrometry multi-target approach.Drug Tes

  [5]. Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv. 2005 Jun;5(3):173-88.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport