147403-65-4

• 常用中文名：1-[(2'-(羟基脒基)[1,1-联苯基]-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯
• 常用英文名：2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester
• CAS号：147403-65-4
• 分子式：C₂₅H₂₄N₄O₄
• 分子量：444.483
• 发布时间：2018-12-24 14:24:25
• 更新时间：2026-07-08 13:16:35

名称

• 中文名: 2-乙氧基-1-((2-(n-羟基甲脒基)-[1,1-联苯]-4-基)甲基)-1H-苯并[d]咪唑-7-羧酸甲酯
• 英文名: methyl 2-ethoxy-3-[[4-[2-[(Z)-N'-hydroxycarbamimidoyl]phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 中文别名: 阿齐沙坦酯中间体; 阿齐沙坦中间体 阿齐沙坦羟胺化物; 1-[(2'-(羟基脒基)[1,1-联苯基]-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯 阿齐沙坦中间体; 1-[(2'-(羟基脒基)[1,1-联苯基]-4-基)甲基]-2-乙氧基-1H; 阿齐沙坦杂质07; 阿齐沙坦中间体 1H-苯并咪唑-7-甲酸甲酯; 阿齐沙坦杂质T; 阿齐沙坦-A02; 阿齐沙坦奥美沙坦酯中间体AZILSTAN KAMEDOXOMIL INTERMEDIATE; 2-乙氧基-1-[[2′-(羟基甲脒基)联苯-4-基]甲基]-1H-苯并咪唑-7-羧酸甲酯; 阿齐沙坦中间体(A1甲酯); 阿奇沙坦羟胺化物; 阿齐沙坦杂质46; 阿齐沙坦INT B 阿齐沙坦-A02; 阿剂沙坦羟胺化物; 2-乙氧基-1-[[2'-[(羟基氨基)亚氨基甲基][1,1'-联苯]-4-基]甲基]-1H-苯并咪唑-7-羧酸甲酯; 1H-苯并咪唑-7-甲酸甲酯; 2-乙氧基-1-[2'-(N'-羟基脒基)联苯-4-基]甲基-1H-苯并[D]咪唑-7-甲酸甲酯; 1-[(2'-(羟基脒基)[1,1-联苯基]-4-基)甲基]; 阿齐沙坦羟胺化物; 阿齐沙坦中间体; (Z) -甲基-2-乙氧基-1-((2'-(N'-羟基氨基甲酰亚胺基)联苯-4-基)甲基)-1H-苯并[D]咪唑-7-羧酸盐; 阿齐沙坦INT B; 1-[[2'-(羟基咪唑)[1,1'-联苯基]-4-基]甲基]-1H-苯并咪唑-2-乙氧基-7-羧酸甲酯; 阿齐沙坦杂质 19; 阿齐沙坦&坎地沙坦酯中间体,1-[(2'-(羟基脒基)[1,1-联苯基]-4-基) 甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸 甲酯; 2-乙氧基-1-[[2'-[(羟基胺基)亚胺基甲基](1,1'-联苯)-4-基]甲基]-1H-苯并咪唑-7-羧酸甲酯; 2-乙氧基-1-((2-(N-羟基甲脒基)-[1,1-联苯]-4-基)甲基)-1H-苯并[D]咪唑-7-羧酸甲酯; 阿齐沙坦-a02; 阿奇沙坦杂质2; 阿齐沙坦中间体1 A1甲酯; 阿齐沙坦 N-羟基甲酯
• 英文别名: 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1; 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)(1,1'-biphenyl)-4; methyl 2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate; methyl 2-ethoxy-3-[[4-[2-[(Z)-N'-hydroxycbamimidoyl]phenyl]phenyl]methyl]benzimidazole-4-cboxylate; methyl 2-ethoxy-1-((2'-((hydroxyimino)(amino)methyl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate; methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxyc bamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; BEN730; 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic acid methyl ester; Methyl 2-Ethoxy-1-[[2'-(hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-7-cbo-xylate; Methyl 2-Ethoxy-3-[2'-(N-hydroxycbamimidoyl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-cboxylic acid; Azilstan N-Hydroxy Methyl Ester; Methyl2-ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylate; Azilstan Impurity 19; Methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-indole-7-cboxylate; Methyl(Z)-2-ethoxy-1-((2'-(N'-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-indole-7-cboxylate; 2-Ethoxy-[[2’-(hydroxyamidino) biphenyl-4-yl)methyl]-1-H-benzimidazole-7cboxylate; Methyl 2-ethoxy-1-((2'-(N-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; 1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester; Methyl 2-ethoxy-1-((2'-(N-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidaz; Methyl 2-ethoxy-1-{[2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl]methyl)]-1H-benzo[d]imidazole-7-carboxylate; 2-Ethoxy-1-｛[2'-(N'-hydroxycbaMiMidoyl)biphenyl-4-yl]Methyl｝-1H-benzo[d]iMidazole-7 -cboxylic acid Methyl ester; T56 BN DNJ B1R DR BYUM&MQ& CO2 IVO1; 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester; QC-8897; (Z)-Methyl2-ethoxy-3-((2'-(N'-hydroxycbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-cboxylate; Methyl 2-ethoxy-1-((2'-(N-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole; 1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic Acid methyl ester; 1-[(2'-(Hydroxyamidino)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-cboxylicacidmethylester; (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-ca; Methyl 2-ethoxy-1-{[2'-(N-hydroxycarbamimidoyl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate; (Z)-methyl 2-ethoxy-1-((2'-(N'-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; Azilstan impurity T; Azilstan Impurity 46; methyl 2-ethoxy-1-{[2'-(N-hydroxycarbamimidoyl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate; Azilstan impurity 21/Methyl 2-ethoxy-1-((2'-(N-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; (Z)-methyl 2-ethoxy-1-((2'-(N'-hydroxycbamimidoyl); methyl 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate; methyl 2-ethoxy-1-{[2'-(N-hydroxycbamimidoyl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-cboxylate; 1H-Benzimidazole-7-carboxylic acid,2-ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-,methyl ester; Methyl 2-Ethoxy-1-[[2’-(hydroxyamidino)biphenyl-4-yl]methyl]-1H-benzimidazole-7-cboxylate; methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate; Azilstan intermediates; 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)(1,1'-biphenyl)-4-yl)methyl)-1h-benzimidazole-7-carboxylic acid methyl ester; Intermediate of Azilstan Medoxomil; Methyl-2-Ethoxy-1-[[2'-Hydroxycbamimidoyl)Biphenyl)-4-yl]-Methyl-1H-Benzimidazole-7-Cboxylate; 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)(1,1'-biphenyl)-4-yl)methyl)-1h-benzimidazole-7-cboxylic acid methyl ester; Azilstan impurity07; (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-cboxylate; 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester; (Z)-Methyl 2-ethoxy-1-((2'-(N'-hydroxycbaMiMidoyl)biphenyl-4-yl)Methyl)-1H-benzo[d]iMidazole-7-cboxylate; Azilstan-20; InterMediate of Azilstan; 2-Ethoxy-1-[[2a€-[(hydroxyamino)iminomethyl][1,1a€-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic Acid Methyl Ester; 2-Ethoxy-1-[[2′-[(hydroxyamino)iminomethyl][1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic Acid Methyl Ester; 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 657.2±65.0 °C at 760 mmHg
• 熔点: 207-209°C
• 分子式: C₂₅H₂₄N₄O₄
• 分子量: 444.483
• 闪点: 351.2±34.3 °C
• 精确质量: 444.179749
• PSA: 109.46000
• LogP: 4.33
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.640
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi

合成路线

139481-44-0 ~85% 147403-65-4

文献：RANBAXY LABORATORIES LIMITED; AZAD, Md Abul Kalam; KSHIRSAGAR, Prakash Bhimaji; SINGH, Shravan, Kumar; TIWARI, Anand, Prakash; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar Patent: WO2013/114305 A1, 2013 ; Location in patent: Page/Page column 15; 16 ;

1403477-45-1 ~7% 147403-65-4 147403-03-0

文献：WO2012/139535 A1, ; Page/Page column 12-13 ;

139481-44-0 ~% 139481-33-7 147403-65-4

文献：WO2012/119573 A1, ; Page/Page column 12-13 ;

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