267243-64-1

• 常用中文名：N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺
• 常用英文名：N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE
• CAS号：267243-64-1
• 分子式：C₂₁H₂₁ClFN₅O₄
• 分子量：461.87400
• 发布时间：2018-12-31 20:35:48
• 更新时间：2024-01-16 11:14:00

名称

• 中文名: N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺
• 英文名: N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)-6-nitroquinazolin-4-amine
• 英文别名: (3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine; (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazoline-4-yl]-amine; I14-9229; (3-CHLORO-4-FLOUROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-NITRO-QUINAZOLINE-4YL]-AMINE; N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine; 4-[N-(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline; (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine

物化性质

• 密度: 1.418g/cm3
• 沸点: 637.065ºC at 760 mmHg
• 分子式: C₂₁H₂₁ClFN₅O₄
• 分子量: 461.87400
• 闪点: 339.085ºC
• 精确质量: 461.12700
• PSA: 105.33000
• LogP: 4.70930
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.649
• 储存条件: 室温

合成路线

267243-68-5 ~% 267243-64-1

文献：Warner-Lambert Company LLC Patent: US6664390 B2, 2003 ; Location in patent: Page column 8 ;

4441-30-9 367-21-5 162012-69-3 ~94% 267243-64-1

文献：Barth, Hubert; Bridges, Alexander James; Heemstra, Ronald J.; Horne, Nicole Marcia; Hughes, Robert Craig; Jacks, Thomas Elliott; McNamara, Dennis Joseph; Schneider, Simon; Steiner, Klaus; Toogood, Peter Laurence; Winters, Roy Thomas Patent: US2004/158065 A1, 2004 ; Location in patent: Page 20 ;

4441-30-9 162012-67-1 ~65% 267243-64-1

文献：Hur, Wooyoung; Velentza, Anastasia; Kim, Sungjoon; Flatauer, Laura; Jiang, Xinnong; Valente, David; Mason, Daniel E.; Suzuki, Melissa; Larson, Brad; Zhang, Jianming; Zagorska, Anna; DiDonato, Michael; Nagle, Advait; Warmuth, Markus; Balk, Steven P.; Peters, Eric C.; Gray, Nathanael S. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5916 - 5919

4441-30-9 367-21-5 865-47-4 162012-69-3 ~% 详细

文献：Barth, Hubert; Steiner, Klaus; Schneider, Simon Patent: US2003/158408 A1, 2003 ;

367-21-5 ~% 267243-64-1

文献：Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397

162012-70-6 ~% 267243-64-1

文献：Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397

上下游产品

上游产品  7
267243-68-5 4441-30-9 367-21-5 162012-69-3
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267243-68-5