N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE

Modify Date: 2024-01-16 11:14:00

N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE Structure
N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE structure
Common Name N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE
CAS Number 267243-64-1 Molecular Weight 461.87400
Density 1.418g/cm3 Boiling Point 637.065ºC at 760 mmHg
Molecular Formula C21H21ClFN5O4 Melting Point N/A
MSDS N/A Flash Point 339.085ºC

 Names

Name N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)-6-nitroquinazolin-4-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.418g/cm3
Boiling Point 637.065ºC at 760 mmHg
Molecular Formula C21H21ClFN5O4
Molecular Weight 461.87400
Flash Point 339.085ºC
Exact Mass 461.12700
PSA 105.33000
LogP 4.70930
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.649

 Synthetic Route

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N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE Structure

N-(3-CHLORO-4-F...

CAS#:267243-64-1

Literature: Warner-Lambert Company LLC Patent: US6664390 B2, 2003 ; Location in patent: Page column 8 ;

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N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE Structure

N-(3-CHLORO-4-F...

CAS#:267243-64-1

Literature: Barth, Hubert; Bridges, Alexander James; Heemstra, Ronald J.; Horne, Nicole Marcia; Hughes, Robert Craig; Jacks, Thomas Elliott; McNamara, Dennis Joseph; Schneider, Simon; Steiner, Klaus; Toogood, Peter Laurence; Winters, Roy Thomas Patent: US2004/158065 A1, 2004 ; Location in patent: Page 20 ;

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N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE Structure

N-(3-CHLORO-4-F...

CAS#:267243-64-1

Literature: Hur, Wooyoung; Velentza, Anastasia; Kim, Sungjoon; Flatauer, Laura; Jiang, Xinnong; Valente, David; Mason, Daniel E.; Suzuki, Melissa; Larson, Brad; Zhang, Jianming; Zagorska, Anna; DiDonato, Michael; Nagle, Advait; Warmuth, Markus; Balk, Steven P.; Peters, Eric C.; Gray, Nathanael S. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5916 - 5919

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Detail
Literature: Barth, Hubert; Steiner, Klaus; Schneider, Simon Patent: US2003/158408 A1, 2003 ;

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N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE Structure

N-(3-CHLORO-4-F...

CAS#:267243-64-1

Literature: Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397

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N-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)-6-NITROQUINAZOLIN-4-AMINE Structure

N-(3-CHLORO-4-F...

CAS#:267243-64-1

Literature: Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397

 Synonyms

(3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine
(3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazoline-4-yl]-amine
I14-9229
(3-CHLORO-4-FLOUROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-NITRO-QUINAZOLINE-4YL]-AMINE
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine
4-[N-(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline
(3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine