21794-55-8

• 常用中文名：柔红酮
• 常用英文名：Daunomycinone
• CAS号：21794-55-8
• 分子式：C₂₁H₁₈O₈
• 分子量：398.36
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-09-30 11:21:22
• 更新时间：2026-07-02 09:35:19
• Daunomycinone (NSC-109351) 是 Daunomycin 的代谢物。Daunomycin 是一种抗生素,具有抗肿瘤活性。

名称

• 中文名: 柔红酮
• 英文名: Daunomycinone
• 中文别名: 表柔比星杂质; 表柔比星 杂质 B(柔红霉素 杂质 A、柔红霉素); 柔红霉素杂质1(柔红霉素 杂质A); 柔红霉酮,10 MM DMSO 溶液; 盐酸表柔比星杂质B/柔红霉素杂质A; 表柔比星(表阿霉素)杂质2(表柔比星(表阿霉素)杂质B); 表柔比星杂质B(柔红霉素); 柔红酮 标准品; 柔红霉酮; 盐酸柔红霉素杂质A; 多柔比星杂质03; 盐酸表柔比星杂质B; 柔红霉素杂质A; 8-乙酰基-7,8,9,10-四氢-6,8,10,11-四羟基-1-甲氧基-5,12-并四苯二酮; (8S,10S)-8-乙酰基-6,8,10,11-四羟基-1-甲氧基-7,8,9,10-四氢并四苯-5,12-酮
• 英文别名: (8S,10S)-8-acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (daunorubicin aglycone, daunorubicinone); leukaemomycinonec; 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-,(8s,10s)-12-naphthacenedione; daunomycinaglicone; daunorubicinaglycone; daunomycinon; Daunorubicinone(D0120000); irubicin Impurity B (Daunomycinone); Danorubicinone; Daunorubicinone ((8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5; Daunorubicinone CRS; Daunomycinon|||Leukaemomycinone C|||NSC 109351|||NSC-109351|||NSC; (8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-tetracenedione; irubicin Impurity B (Daunorubicin Impurity A, Daunomycinone); DAUNOMYCINONE; 5,12-naphthacenedione,8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-me; (8S,10S)-8-acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; (8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Daunomycinone, 10 mM in DMSO; 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S-cis)-5,12-Naphthacenedione; (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-Methoxy- -5,12-naphthacenedione; DaunorubicinoneQ: What is Daunorubicinone Q: What is the CAS Number of Daunorubicinone Q: What is the storage condition of Daunorubicinone Q: What e the applications of Daunorubicinone; Daunorubicin Impurity 1(Daunorubicin Impurity A); irubicin Hydrochloride Impurity B; 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S,10S); daunomycinone; (8s,10s)-thoxy; irubicin hydrochloride impurity B/daunorubicin impurity A; irubicin Impurity

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 677.4±55.0 °C at 760 mmHg
• 熔点: 208-210°C
• 分子式: C₂₁H₁₈O₈
• 分子量: 398.36
• 闪点: 243.4±25.0 °C
• 精确质量: 398.100159
• PSA: 141.36000
• LogP: 2.93
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.713
• 储存条件: -20°C Freezer

生物活性

• 描述: Daunomycinone (NSC-109351) 是 Daunomycin 的代谢物。Daunomycin 是一种抗生素,具有抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943). Toxicol Appl Pharmacol. 1974 Mar;27(3):517-26.

  [2]. Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20(3):333-53.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9295500 CHEMICAL NAME : 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1 -methoxy-, (8S, 10S)- CAS REGISTRY NUMBER : 21794-55-8 LAST UPDATED : 199409 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C21-H18-O8 MOLECULAR WEIGHT : 398.39 WISWESSER LINE NOTATION : L E6 C666 BV MVT&&&J DQ FQ HV1 HQ KQ RO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 2 umol/L REFERENCE : CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year: 68,115,1978

安全

• 危险品运输编码: UN 2811 6.1 / PGIII

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