147-84-2

147-84-2结构式

常用中文名：二乙基二硫代氨基甲酸
常用英文名：Diethyldithiocarbamic acid
CAS号：147-84-2
分子式：C₅H₁₁NS₂
分子量：149.27800
相关类别：信号通路抗感染 HIV
发布时间：2016-08-05 15:13:21
更新时间：2024-01-06 11:09:16
二硫代碳酸(二乙基二硫代氨基甲酸)是铜胶结速率的促进剂。双硫卡宾(二乙基二硫代氨基甲酸)可降低HIV感染的发生率,并可增强高危乳腺癌症的辅助免疫治疗[1][2][3]。

中文名	二乙基二硫代氨基甲酸
英文名	Diethyldithiocarbamic acid

描述	二硫代碳酸(二乙基二硫代氨基甲酸)是铜胶结速率的促进剂。双硫卡宾(二乙基二硫代氨基甲酸)可降低HIV感染的发生率,并可增强高危乳腺癌症的辅助免疫治疗[1][2][3]。
相关类别	研究领域 >> 癌症信号通路 >> 抗感染 >> HIV 研究领域 >> 感染
体外研究	二硫代氨基甲酸酯与铜2+溶液反应生成二乙基二硫代氨基甲酸铜配合物,提高了的胶结速率[1]。二硫代卡巴是一种具有较强抗氧化能力和螯合活性的化合物[2]。
体内研究	二硫代卡巴改善新生和老年小鼠的免疫反应。二硫代卡巴在不降低抗肿瘤活性的情况下可预防顺铂对动物的肾毒性。在艾滋病模型中,二硫代卡巴减少淋巴结病和高 γ 球蛋白血症,恢复免疫能力,延长生存[2]。
参考文献	[1]. Abeer A.El-Saharty, et al. Sodium diethyldithiocarbamate as accelerator of the rate of copper cementation. The Egyptian Journal of Aquatic Research. 2015 Dec, Volume 41(4):289-293. [2]. Hersh EM, et al. Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized, double-blind, placebo-controlled, multicenter study. JAMA. 1991 Mar 27;265(12):1538-44. [3]. Dufour P, et al. Sodium dithiocarb as adjuvant immunotherapy for high risk breast cancer: a randomized study. Biotherapy. 1993;6(1):9-12.

密度	1.079
沸点	176.4±23.0 °C
熔点	143-144 °C
分子式	C₅H₁₁NS₂
分子量	149.27800
精确质量	149.03300
PSA	74.13000
LogP	1.54290
蒸汽压	1.1mmHg at 25°C
折射率	1.5300
分子结构	1、摩尔折射率：44.12 2、摩尔体积（cm³/mol）：137.3 3、等张比容（90.2K）：355.1 4、表面张力（dyne/cm）：44.6 5、极化率（10-24cm3）：17.49
计算化学	1.疏水参数计算参考值（XlogP）:1.6 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:2 5.互变异构体数量:无 6.拓扑分子极性表面积36.3 7.重原子数量:8 8.表面电荷:0 9.复杂度:78.5 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

Name:	Diethyldithiocarbamic acid 97% Material Safety Data Sheet
Synonym:	Diethyldithione
CAS:	147-84-2

Section 1 - Chemical Product MSDS Name:Diethyldithiocarbamic acid 97% Material Safety Data Sheet
Synonym:Diethyldithione

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
147-84-2	Diethyldithiocarbamic acid	97%	205-701-7

Hazard Symbols: XN
Risk Phrases: 22 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes, respiratory system and skin.Mutagen.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 147-84-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C5H11NS2
Molecular Weight: 149.30

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 147-84-2: EZ4550000 LD50/LC50:
CAS# 147-84-2: Oral, rat: LD50 = 1 gm/kg.
Not available.
Carcinogenicity:
Diethyldithiocarbamic acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 147-84-2: No information available.
Canada
CAS# 147-84-2 is listed on Canada's DSL List.
CAS# 147-84-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 147-84-2 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

海关编码	2930909090

上游产品 0
下游产品 10
106128-43-2 95-30-7 97-77-8 686-07-7
102732-64-9 75-15-0 109-89-7 75-04-7
61998-04-7 5347-18-2

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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