72896-40-3

• 常用中文名：苯甲酰氧化芍药苷
• 常用英文名：Benzoyloxypeoniflorin
• CAS号：72896-40-3
• 分子式：C₃₀H₃₂O₁₃
• 分子量：600.567
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-10-17 21:14:46
• 更新时间：2024-01-10 15:22:41
• Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根,是 tyrosinase 抑制剂,对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂,Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。

名称

• 中文名: 苯甲酰氧化芍药苷
• 英文名: ((1aR,1a1S,2R,3aR,5S,5aR)-5a-(((2S,3R,4S,5S,6R)-6-((benzoyloxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2-hydroxy-5-methyltetrahydro-1H-3,4-dioxa-2,5-methanocyclobuta[cd]pentalen-1a1(3aH)-yl)methyl 4-hydroxybenzoate
• 英文别名: {(1R,2S,3R,5R,6R,8S)-3-[(6-O-Benzoyl-β-D-glucopyranosyl)oxy]-6-hydroxy-8-methyl-9,10-dioxatetracyclo[4.3.1.0.0]dec-2-yl}methyl 4-hydroxybenzoate; β-benzoyloxypaeoniflorin; Benzoic acid, 4-hydroxy-, [(1aR,2S,3aR,5R,5aR,5bS)-1a-[(6-O-benzoyl-β-D-glucopyranosyl)oxy]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl ester; Benzoyloxypeoniflorin; Benzoyloxypaeoniflorin

物化性质

• 密度: 1.6±0.0 g/cm3
• 沸点: 789.1±0.0 °C at 760 mmHg
• 分子式: C₃₀H₃₂O₁₃
• 分子量: 600.567
• 闪点: 258.6±0.0 °C
• 精确质量: 600.184265
• PSA: 190.67000
• LogP: 5.22
• 外观性状: 粉末
• 蒸汽压: 0.0±0.0 mmHg at 25°C
• 折射率: 1.699
• 储存条件: 2-8℃

生物活性

• 描述: Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根,是 tyrosinase 抑制剂,对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂,Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶
• 靶点:

  IC50: 0.453 mM (Mushroom tyrosinase)[1] NF-κB[2]

• 参考文献:

  [1]. Ding HY, et al. Tyrosinase inhibitors isolated from the roots of Paeonia suffruticosa. J Cosmet Sci. 2009 May-Jun;60(3):347-52.

  [2]. Lu Y, et al. The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS. Evid Based Complement Alternat Med. 2019 Mar 3;2019:6150357.

  [3]. Koo YK, et al. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Pharmazie. 2010 Aug;65(8):624-8.

安全

• 危害码 (欧洲): Xi