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26844-12-2

26844-12-2结构式

常用中文名：吲哌胺
常用英文名：Indoramin
CAS号：26844-12-2
分子式：C₂₂H₂₅N₃O
分子量：347.45300
相关类别：原料药循环系统用药抗高血压病药
发布时间：2018-06-26 17:18:06
更新时间：2024-01-04 09:59:21
吲哚美辛是一种口服活性抗高血压药物。吲哚美辛对α1A肾上腺素受体也有选择性[1]。

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中文名	吲哚拉明
英文名	N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
中文别名	3-[2-(4-苯酰胺-1-哌啶)乙基]吲哚吲哌胺
英文别名	3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol Indoramine [INN-French] N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide 3-[2-(4-benzamido-1-piperidyl)ethyl]indole INDORAMIN Indoramine 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole Indoramina [INN-Spanish] EINECS 248-041-5 Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl) Indoraminum [INN-Latin]

描述	吲哚美辛是一种口服活性抗高血压药物。吲哚美辛对α1A肾上腺素受体也有选择性[1]。
相关类别	研究领域 >> 内分泌信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
参考文献	[1]. M Eltze, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73.

密度	1.21g/cm3
沸点	600ºC at 760mmHg
熔点	208-210°
分子式	C₂₂H₂₅N₃O
分子量	347.45300
闪点	316.7ºC
精确质量	347.20000
PSA	48.13000
LogP	3.93360
蒸汽压	2.36E-14mmHg at 25°C
折射率	1.657

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5395900

CHEMICAL NAME :: Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-

CAS REGISTRY NUMBER :: 26844-12-2

BEILSTEIN REFERENCE NO. :: 0494035

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H25-N3-O

MOLECULAR WEIGHT :: 347.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

海关编码	2933990090

上游产品 1
26844-47-3
下游产品 0

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%