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2564-35-4

2564-35-4结构式

常用中文名：2′-脱氧鸟苷 5′-(四氢三磷酸酯)
常用英文名：2'-Deoxyguanosine 5'-(Tetrahydrogen Triphosphate)
CAS号：2564-35-4
分子式：C₁₀H₁₆N₅O₁₃P₃
分子量：507.18
相关类别：信号通路细胞周期/DNA损伤 DNA/RNA合成
发布时间：2017-06-29 19:43:24
更新时间：2024-01-11 12:53:34
dGTP(2’-脱氧鸟苷-5’-三磷酸)是一种鸟苷核苷酸,可用于脱氧核糖核酸的合成。鸟苷核苷酸(GDP、GTP、dGDP和dGTP)对8-O-GDP(8-O-GDP)、8-O-dGTP、8-O-GTP和8-O-dGTP的氧化损伤高度敏感[1]。

中文名	2'-脱氧鸟苷 5'-(四氢三磷酸酯)
英文名	dGTP
英文别名	deoxyguanosinetriphosphate 2'-deoxy-GTP 5'-deoxyguanosine triphosphate DGTP LI-SALT deoxy-gtp 5'-DGTP 2'-DEOXYGUANOSINE-5'-TRIPHOSPHORIC ACID, DISODIUM DGTP,LI DGTP,NA2H2 2'-Deoxyguanosine 5'-(Tetrahydrogen Triphosphate) EINECS 219-887-2

描述	dGTP(2’-脱氧鸟苷-5’-三磷酸)是一种鸟苷核苷酸,可用于脱氧核糖核酸的合成。鸟苷核苷酸(GDP、GTP、dGDP和dGTP)对8-O-GDP(8-O-GDP)、8-O-dGTP、8-O-GTP和8-O-dGTP的氧化损伤高度敏感[1]。
相关类别	研究领域 >> 癌症研究领域 >> 感染信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
参考文献	[1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

密度	2.63g/cm3
沸点	989.5ºC at 760 mmHg
分子式	C₁₀H₁₆N₅O₁₃P₃
分子量	507.18
闪点	552.2ºC
PSA	313.96000
LogP	0.15110
蒸汽压	0mmHg at 25°C
折射率	1.904
储存条件	-20°C，密封，干燥

Name:	2 -Deoxyguanosine-5 -Triphosphate Trisodium Salt Dihydrate Material Safety Data Sheet
Synonym:	DGT
CAS:	2564-35-4

Section 1 - Chemical Product MSDS Name:2 -Deoxyguanosine-5 -Triphosphate Trisodium Salt Dihydrate Material Safety Data Sheet
Synonym:DGT

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
2564-35-4	dGTP Trisodium Salt dihydrate	app. 100	219-887-2

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Wash clothing before reuse.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 2564-35-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not applicable.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: C10H13N5O13P3Na3.2H2O
Molecular Weight: 609.0343

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizers.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of phosphorus, irritating and toxic fumes and gases, carbon dioxide, sodium oxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 2564-35-4: MF8782500 LD50/LC50:
Not available.
Carcinogenicity:
dGTP Trisodium Salt dihydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 2564-35-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 2564-35-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 2564-35-4 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8782500

CHEMICAL NAME :: Guanosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 2564-35-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N5-O13-P3

MOLECULAR WEIGHT :: 507.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,261,1996

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