134098-61-6

• 常用中文名：唑螨酯
• 常用英文名：Fenpyroximate
• CAS号：134098-61-6
• 分子式：C₂₄H₂₇N₃O₄
• 分子量：421.48900
• 相关类别： 化学农药原药 杀虫剂 杀螨剂
• 发布时间：2018-06-05 08:00:00
• 更新时间：2026-07-07 11:12:28
• (E) -苯吡肟是一种有效的杀螨剂[1]。

名称

• 中文名: 唑螨酯
• 英文名: fenpyroximate
• 中文别名: 丙酮中唑螨酯溶液标准物质; E)-ALPHA-(1,3-二甲基-5-苯氧基吡唑-4-亚甲基氨基氧)对甲苯甲酸叔丁酯,杀螨王,霸螨灵; (E)-唑螨酯 标准品; (E)-唑螨酯; 唑螨酯标准品; (E)-FENPYROXIMATE,10NG/UL 标准品; 甲苯中(E)-唑螨酯; (E)-Α-(1,3-二甲基-5-苯氧基吡唑-4-基亚甲基氨基氧)对甲苯甲酸叔丁酯; 霸螨灵; 甲醇中(E)-唑螨酯溶液,100ΜG/ML; 丙酮中(E)-唑螨酯溶液标准物质; (E)-唑螨酯溶液,100PPM; (E) -芬咯肟酸盐; 乙腈中(E)-唑螨酯; 杀螨王; 甲苯中唑螨酯标准品; 甲醇中E唑螨酯溶液; E唑螨酯溶液; (E)-Α-(1,3-二甲基-5-苯氧基吡唑-4-亚甲基氨基氧)对甲苯甲酸性丁酯; (E)-alpha-(1,3-二甲基-5-苯氧基吡唑-4-亚甲基氨基氧)对甲苯甲酸叔丁酯
• 英文别名: 12α-Fumitremorgin C; T-BUTYL(E)-ALPHA-(1,3-DIMETHYL-5-PHENOXYPYRAZOL-4-YLMETHYLENEAMINO-OXY)-P-TOLUATE; Fenbpyroximate; Fenpyroximate Reference Material; 4-[[[[(E)-(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoic acid 1,1-dimethylethyl ester; Trophloabul; DANITORON; 134-6 Fenpyroximate; Danitrophloabul; (E)-Fenpyroximate in Acetonitrile; Fenpyroximate SC chemical pesticide Acicide Products For Ticks 134-6; H-VAL-TRP-OH 24-9; 4-[[[[(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]-benzoic acid 1,1-dimethylethyl ester; Fenpyroximate Standd; Fenpyroximate in acetone; Danitron,Ortus; mite azole; t-butyl(e)-alpha-(1,3-dimethyl-5-phenoxypyrazol-4-ylmethyleneaminooxy)-p-tol; (E)-Fenpyroximate 10 μg/mL in Cyclohexane; 4-[[(E)-(1,3-dimethyl-5-phenoxy-4-pyrazolyl)methylideneamino]oxymethyl]benzoic acid tert-butyl ester; Fenpyroximate 10.0 μg/ml Acetonitrile; 4-[(E)-[1,3-Dimethyl-5-phenoxy-1H-pyrazole-4-yl]methyleneaminooxymethyl]benzoic acid tert-butyl ester; (E)-Fenpyroximate; tert-butyl (E)-α-(1,3-dimethyl-5-phenoxypyrazol-4-ylmethyleneaminooxy)-p-toluate; tert-butyl (e)-4-(((((1,3-dimethyl-5-phenoxy-1h-pyrazol-4-yl)methylene)amino)oxy)methyl)benzoate; Benzoic acid, 4-(E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methyleneaminooxymethyl-, 1,1-dimethylethyl ester; Acaban(TM); benzoicacid,4-(((((1,3-dimethyl-5-phenoxy-1h-pyrazol-4-yl)methylene)amino)oxy; tert-butyl(E)-α-(1,3-dimethyl-5-phenoxy-pyrazol-4-ylmethyleneaminoxy)-ptoluate; 1,1-dimethylethyl (e)-4-(((((1,3-dimethyl-5-phenoxy-1h-pyrazol-4-yl)methylene)amino)oxy)methyl)benzoate; tert-butyl-(E)-α-(1,3-dimethyl-5-phenoxypyrazol-4-yl methyleneaminooxy)-p-toluate; L13545000AL(E)-FenpyroximatE10μg/mLin Aceto; uate; ORTUS; KIRON; Dodemorph Impurity 5; DANITRON; PAMANRIN; 4-[[[[(E)-(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoic acid tert-butyl ester; L13545000CY (E)-FenpyroximatE10μg/mLin Cyclo; E-1,1-dimethylethyl 4-(((1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl) methylene) amino) oxy methyl benzoate; tert-butyl 4-[({[(E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylidene]amino}oxy)methyl]benzoate; (E)-Fenpyroxim; (E)-Fenpyroximate Solution in Methanol, 100μg/mL; MFCD00274596; fenproximate; 4-(((((1,3-dimethyl-5-phenoxy-1h-pyrazol-4-yl)methylene)amino)oxy)methyl)-,1,1-dimethylethylester,benzoicaci; Phenproximate; 1,1-dimethylethylester,(e)-)methyl); tert-Butyl 4-[[[(E)-[(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate; (E)-Fenpyroximate 1000 μg/mL in Acetone; 1,1-dimethylethyl 4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate; nni850; (E)-Fenpyroximate 10 μg/mL in Acetonitrile; (E)-Fenpyroximate 100 μg/mL in Cyclohexane

物化性质

• 密度: 1.13 g/cm3
• 沸点: 546.2ºC at 760 mmHg
• 熔点: 99-102°C
• 分子式: C₂₄H₂₇N₃O₄
• 分子量: 421.48900
• 闪点: 284.1ºC
• 精确质量: 421.20000
• PSA: 74.94000
• LogP: 5.02680
• 外观性状: 白色结晶粉末
• 储存条件: 室温，干燥，密封
• 稳定性:

  对兔皮肤和眼睛有轻度刺激作用。

• 分子结构:

  1、摩尔折射率：120.19

  2、摩尔体积（cm³/mol）：371.1

  3、等张比容（90.2K）：930.7

  4、表面张力（dyne/cm）：39.5

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：47.65

  7、单一同位素质量：421.200156 Da

  8、标称质量：421 Da

  9、平均质量：421.4889 Da

• 计算化学:

  1.疏水参数计算参考值（XlogP）:4.9

  2.氢键供体数量:0

  3.氢键受体数量:6

  4.可旋转化学键数量:9

  5.互变异构体数量:无

  6.拓扑分子极性表面积74.9

  7.重原子数量:31

  8.表面电荷:0

  9.复杂度:592

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:1

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：白色结晶

  2. 密度（g/mL,20℃）：1.25

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：101.7

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,KPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（Pa,25ºC）：>7.47×10^-6

  12. 饱和蒸气压（KPa,20ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：甲苯0.61g/L，丙酮154g/L，甲醇15.1g/L，己烷4.0g/L，难溶于水

生物活性

• 描述: (E) -苯吡肟是一种有效的杀螨剂[1]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Motoba. K, et al. Species-specific detoxification metabolism of fenpyroximate, a potent acaricide.

毒性和生态

毒理学数据: 原药对大鼠急性经口LD 50为245～480mg/kg，急性经皮LD 50>2000mg/kg，急性吸入LC 50为0.33mg/L(雄）。对兔皮肤和眼睛有轻度刺激作用。90d饲喂试验对大鼠经口无作用剂量为20mg/kg，狗为2mg/kg。2年慢性毒性试验大鼠无作用剂量25mg/kg。动物试验无致畸、致癌、致突变作用。鲤鱼LC 50为6.1×10 ^-9g/L (48h)。 CHEMICAL IDENTIFICATION RTECS NUMBER : DG9081200 CHEMICAL NAME : Benzoic acid, 4-(((((1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methyle ne)amino)oxy)methyl)-, 1,1-dimethylethyl ester, (E)- CAS REGISTRY NUMBER : 134098-61-6 LAST UPDATED : 199607 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C24-H27-N3-O4 MOLECULAR WEIGHT : 421.54 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 330 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 440 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2730 mg/kg/13W-C TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - urine volume decreased Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6552 mg/kg/2Y-C TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 4550 mg/kg/13W-I TOXIC EFFECTS : Cardiac - change in rate Liver - changes in liver weight REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 5460 mg/kg/52W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Cardiac - change in rate Gastrointestinal - hypermotility, diarrhea REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

安全

• 危害码 (欧洲): Xn;N
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin .
• 安全声明 (欧洲): S26-S36/37/39
• WGK德国: 3.0
• 危险类别: 9.0
• 海关编码: 2942000000

制备

1、 5-氯-1，3-二甲基-4-吡唑甲醛的制备 先用乙酰乙酸乙酯与甲肼作用，生成1，3-二甲基吡唑-5-酮。然后加入到三氯氧磷-二甲基甲酰胺溶液中。于110～115℃反应8h，得5-氯-1，3-二甲基-4-吡唑甲醛。

2、 1，3-二甲基-5-苯氧基-4-吡唑甲醛的制备 先将苯酚、甲醇钠的甲醇溶液加热回流，蒸出甲醇，加入DMF和上步反应产物，于100℃反应4h，减压回收DMF后，冷却、加水、用二氯乙烷萃取，得1，3-二甲基-5-苯氧基-4-吡唑甲醛。

3、 1,3-二甲基-5-苯氧基-4-吡唑甲醛肟的制备将上步产物溶于甲醇中，加入盐酸羟胺，在搅拌下加入氢氧化钾溶液，于60℃反应1h，减压蒸去甲醇，水洗干燥后得白色1，3-二甲基-5-苯氧基-4-吡唑甲醛肟。

4、 唑螨酯的合成 将上步产物与4-溴甲基苯甲酸特丁酯（合成方法参见特开昭63-183564， 63-267754）在丙酮溶剂中，加入适量碳酸钾，回流反应8h得唑螨酯，目的产物为反式异构体。

海关

海关编码	2942000000