33396-29-1

• 常用中文名：红霉素A烯醇醚
• 常用英文名：Erythromycin A Enol Ether
• CAS号：33396-29-1
• 分子式：C₃₇H₆₅NO₁₂
• 分子量：715.91100
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-02-20 08:00:00
• 更新时间：2026-07-06 12:48:07
• Erythromycin A enol ether 是一种 Erythromycin A(大环内酯抗生素)的酸性降解产物,无抗菌作用。

名称

• 中文名: 红霉素A烯醇醚
• 英文名: Erythromycin A Enol Ether
• 中文别名: 红霉素A烯醇乙醚; (2R,3R,4S,5R,8R,9S,10S,11R,12R)-11-((4-(二甲氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-5-乙基-3,4-二羟基-9-((5-羟基-4-甲氧基-4,6-二甲基四氢-2,H-吡喃2-基)氧)-2,4,8,10,12,14-六甲基-6,15-二氧杂环[10.2.1]十五碳-1-烯-7-酮; 红霉素杂质E[红霉素 A 烯醇醚]; 红霉素A烯醇醚 标准品; 红霉素杂质5(红霉素杂质E); 红霉素杂质E(红霉素A烯醇醚); 红霉素杂质E(红霉素A醇醚); 红霉素杂质E 标准品; 红霉素杂质 5; 红霉素杂质05
• 英文别名: Erythromycin A Enol EtherI; 6,9-Epoxy-8,9-didehydro-9-deoxo-6-deoxyerythromycin; Erythromycin Impurity E/Erythromycin A Enol Ether/(2R,3R,4S,5R,8R,9S,10S,11R,12R)-9-[(2,6-dideoxy-3- C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]- 5-ethyl-3,4-dihydroxy-2,4,8,10,12,14-hexamethyl- 11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylohexopyr; 9-Deoxo-6-deoxy-6,9-epoxy-8,9-didehydroerythromycin; Erythromycin Impurit E:(erythromycin A enol ether); Erythromycin impurity 05; 9-Deoxo-6-deoxy-6,9-oxy-8,9-didehydroerythromycin; Erythromycin Steate Impurity E; JFVYXJKGJMUG-POECJHBWSA-N; Erythromycin Impurity 5(Erythromycin Impurity E); 8,9-anhydroerythromycin A; Isoniazid Impurity 16; 8,9-anhydroerythromycin 6,9-hemiketal; Erythromycin Lactobionate Impurity E; (2R,3R,4S,5R,8R,9S,10S,11R,12R)-9-[(2,6-dideoxy-3-C-methyl- 3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-5-ethyl-3,4-dihydroxy- 2,4,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)- β-D-xylohexopyranosyl]oxy]-6,15-dioxabicyclo[10.2.1]pentadec- 1-en-7-one; Erythromycin Impurity E (Erythromycin A Enol Ether); 8,9-anhydroerythromycin A 6,9-hemiacetal; 8,9-anhydroerythromycin A 6,9-hemiketal; Erythromycin Ethylsuccinate Impurity E; 6β,9-oxy-8,9-didehydro-9-deoxo-6-deoxyerythromycin; 11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-5-ethyl-3,4-dihydroxy-9-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-2,4,8,10,12,14-hexamethyl-6,15-dioxa-bicyclo[10.2.1]pentadec-1-en-7-one; Erythromycin Impurity 5; Erythromycin, 8,9-didehydro-9-deoxo-6-deoxy-6,9-oxy; erythromycin hemiketal; (6R)-6-Deoxy-9-deoxo-6,9-oxy-8,9-didehydroerythromycin; 6-Deoxy-9-deoxo-8,9-didehydro-6,9-epoxyerythromycin; Erythromycin impurity B; 6-Deoxy-9-deoxo-8,9-didehydro-6,9-oxyerythromycin; Erythromycin Estolate Impurity E; EM 523; Inhibitor,inhibit,Acidic,Erythromycin A enol ether,deadation; Erythromycin A enol ether, EvoPure; 6,9-oxy-8,9-didehydro-9-deoxo-6-deoxyerythromycin

物化性质

• 密度: 1.2g/cm3
• 沸点: 791.6ºC at 760mmHg
• 熔点: 133-135ºC
• 分子式: C₃₇H₆₅NO₁₂
• 分子量: 715.91100
• 闪点: 432.6ºC
• 精确质量: 715.45100
• PSA: 165.84000
• LogP: 2.89230
• 折射率: 1.542
• 储存条件: -20°C Freezer

生物活性

• 描述: Erythromycin A enol ether 是一种 Erythromycin A(大环内酯抗生素)的酸性降解产物,无抗菌作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. A Deubel, et al. Development of an enhanced separation of erythromycin and its related substances by liquid chromatography. J Pharm Biomed Anal. 2007 Jan 17;43(2):493-8.

  [2]. Abdolreza Hassanzadeh, et al. Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution. J Phys Chem A. 2007 Oct 11;111(40):10098-104.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

合成路线

114-07-8 ~19% 105882-69-7 33396-29-1

文献：Journal of Organic Chemistry, , vol. 52, # 6 p. 990 - 996

114-07-8 ~% 33396-29-1

文献：Kibwage, Isaac O.; Busson, Roger; Janssen, Gerard; Hoogmartens, Jos; Vanderhaeghe, Hubert Journal of Organic Chemistry, 1987 , vol. 52, # 6 p. 990 - 996

105882-69-7 ~% 33396-29-1

文献：Journal of Organic Chemistry, , vol. 52, # 6 p. 990 - 996

105900-46-7 ~% 33396-29-1

文献：Journal of Organic Chemistry, , vol. 52, # 6 p. 990 - 996

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