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523-87-5生产厂家

523-87-5价格

相关CAS号：
523-87-5 118-23-0
4024-34-4 83-98-7
642-58-0 13358-73-1
58-73-1 88637-37-0
170082-18-5 1381965-24-7
1158522-08-7 1243462-60-3
1243313-60-1 1243371-00-7
940364-43-2 1956309-95-7
134104-43-1 131615-57-1
6906-52-1 930439-75-1

523-87-5

523-87-5结构式
523-87-5结构式

化源商城直购

中文名 茶苯海明
英文名 dimenhydrinate
中文别名 1,3-二甲基-8-氯-3,7-二氢-1H-嘌呤-2,6-二酮 N,N-二甲基-2-(二苯基甲氧基)乙胺
1,3-二甲基-8氯-3,7-二氢-1H-嘌呤,6二酮-N,N-二甲基-2-(二苯基甲氧基)乙胺盐
英文别名 faston
dromyl
N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate
8-Chlor-1,3-dimethyl-3,7-dihydro-purin-2,6-dion,Verbindung mit (2-Benzhydryloxy-aethyl)-dimethyl-amin
gravol
epha
EINECS 208-350-8
vomexa
amosyt
MFCD00054265
emedyl
dramyl
emes
Dimenhydrinate
8-chloro-1,3-dimethyl-3,7-dihydro-purine-2,6-dione,compound with (2-benzhydryloxy-ethyl)-dimethyl-amine
Dimenhydrinase
DiMate
描述 Dimenhydrinate是一种抗催吐剂, 和抗组胺剂, 用作晕车的补救措施。
相关类别
沸点 343.7ºC at 760 mmHg
熔点 102-107ºC
分子式 C24H28ClN5O3
分子量 469.96400
闪点 101.5ºC
精确质量 469.18800
PSA 85.15000
LogP 2.96790
外观性状 结晶白色粉末
储存条件 2-8°C
水溶解性 Slightly soluble (0.1-1 g/100 mL at 22 ºC)
Section 1. Chemical Product and Company Identification
Catalog
Dimenhydrinate
Common Name/DI127
Number(s).
Trade Name
523-87-5
CAS#
Manufacturer
SPECTRUM CHEMICAL MFG. CORP.RTECSXH5082000
TSCATSCA 8(b) inventory:
Dimenhydrinate
Commercial Name(s)Not available.
CI# Not available.
Synonym8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd.
IN CASE OF EMERGENCY
with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1);
Anautine;
Andramine;
Aviomarin;
Dimenhydrinate;
Diphenhydramine 8-chlorotheophylline;
Diphenhydrinate;
Ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-,
compd. with 8-chlorotheophylline;
Gravinol
Novamin;
Novamine;
Teodramin;
O-Benzhydryldimethylaminoethanol 8-chlorotheophyllinate;
Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline;
2-(Benzhydryloxy)-N,N-dimethylethylamine
compd. with 8-chlorotheophylline;
Chloranautine;
8-Chlorotheophylline, compd.
with 2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1);
Diamarin;
Dramamin;
Dramamine;
Dramarin;
Dramyl;
Dromyl;
Eldodram;
Gravinol (antiemetic);
Gravol;
Menhydrinate;
Neo-navigan;
Permital;
Supremal;
Travelin;
Travelmin;
Vomex A;
Xamamina
Chemical NameTheophylline, 8-chloro-, compd. with
2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1)
Not available.CALL (310) 516-8000
Chemical Family
Dimenhydrinate
Chemical FormulaC17H21NO.C7H7ClN4O2
SPECTRUM CHEMICAL MFG. CORP.
Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3) % by Weight
NameCAS #
1) Dimenhydrinate523-87-5100
Toxicological DataNot applicable.
on Ingredients
Section 3. Hazards Identification
Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin Contact
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops. Cold water may be used.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
Serious IngestionNot available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Flammable LimitsNot available.
Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of shocks, of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
of Various Substances
Dimenhydrinate
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Special Remarks onMaterial in powder form, capable of creating a dust explosion.
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
dust explosion hazard.
Hazards
Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.
Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately
and show the container or the label. Keep away from incompatibles such as oxidizing agents.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage
Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure LimitsNot available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline powder.)OdorOdorless.
TasteNot available.
Molecular Weight469.96 g/mole
ColorWhite.
pH (1% soln/water)Not available.
Not available.
Boiling Point
Melting Point102-107°C (215.6-224.6°F)
Not available.
Critical Temperature
Specific GravityNot available.
Vapor PressureNot applicable.
Vapor DensityNot available.
VolatilityNot available.
Not available.
Odor Threshold
Water/Oil Dist. Coeff.Not available.
Not available.
Ionicity (in Water)
Dispersion PropertiesNot available.
Dimenhydrinate
SolubilitySoluble in cold water.
Freely soluble in alcohol.
Soluble in chloroform , benzene.
Insoluble in diethyl ether.
Section 10. Stability and Reactivity Data
StabilityThe product is stable.
Not available.
Instability Temperature
Conditions of InstabilityExcess heat, dust generation, incompatible materials
Incompatibility with variousReactive with oxidizing agents.
substances
CorrosivityNon-corrosive in presence of glass.
Not available.
Special Remarks on
Reactivity
Special Remarks onNot available.
Corrosivity
PolymerizationWill not occur.
Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsAcute oral toxicity (LD50): 1320 mg/kg [Rat].
Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onMay affect genetic material (mutagenic)
Chronic Effects on Humans
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: May be harmul is swallowed. May cause dry mouth, adbominal distress vomiting, nausea,
diarrhea or constipaton, anorexia. May affect behavior (central nervous system (drowsiness, lethargy, fatigue.
excitement, hallucinations; hypnosis, convulsions, coma), cardiovascular system (cardiac arrhythmias).
Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products
may arise.
Toxicity of the ProductsThe products of degradation are as toxic as the product itself.
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation
Dimenhydrinate
Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14. Transport Information
DOT Classification
Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
California prop. 65: This product contains the following ingredients for which the State of California has found
Federal and State
to cause birth defects which would require a warning under the statute: No products were found.
Regulations
TSCA 8(b) inventory: Dimenhydrinate
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has
Proposition 65found to cause cancer which would require a warning under the statute: No products were found.
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
No. 208-350-8).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Listed on National Inventory (KECI).
Philippines: Listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC)R22- Harmful if swallowed.S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
Dimenhydrinate
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH5082000
CAS REGISTRY NUMBER :
523-87-5
LAST UPDATED :
199701
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C17-H21-N-O.C7-H7-Cl-N4-O2
MOLECULAR WEIGHT :
470.02
WISWESSER LINE NOTATION :
T56 BM DN FNVNVJ CG F H &622

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Brain and Coverings - increased intracranial pressure Behavioral - convulsions or effect on seizure threshold Cardiac - arrhythmias (including changes in conduction)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
11400 ug/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
114 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - arrhythmias (including changes in conduction)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
203 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
149 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
333 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3669 No. of Facilities: 98 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1754 (estimated) No. of Female Employees: 962 (estimated)

符号 GHS07
GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
个人防护装备 dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲) Xn:Harmful
风险声明 (欧洲) R22
安全声明 (欧洲) 22-26-36/37/39-53
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 XH5082000
海关编码 2933990090
海关编码 2933990090
中文概述 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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