142103-12-6

• 常用中文名：3'-脱氧-5'-O-DMT-5-甲基尿苷2'-CE亚磷酰胺
• 常用英文名：5-Me-3’-dU-2’-phosphoramidite
• CAS号：142103-12-6
• 分子式：C₄₀H₄₉N₄O₈P
• 分子量：744.81
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2016-10-06 09:04:33
• 更新时间：2026-07-04 08:16:00
• 5-Me-3'-dU-2'-磷脒是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 3'-脱氧-5'-O-DMT-5-甲基尿苷2'-CE亚磷酰胺
• 英文名: 3'-dt cep
• 中文别名: 5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧-5-甲基尿苷 2'-[2-氰基乙基 N,N-二异丙基氨基亚磷酸酯]; 5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧-5-甲基尿苷 2'-[2-氰基乙基 N,N-二异丙基氨基亚磷酸酯; (2R,3R,5S)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-2-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
• 英文别名: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyluridine 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-dT; 3'-DT C; 5’-O-DMTr-3’-deoxy-5-methyluridine-2’-CED-phosphoramidite; 3'-Deoxy-5'-O-DMT-5-methyluridine 2'-CE phosphoramidite; Diisopropyl-phosphoramidous acid (2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester; 5-METHYL-3'-DU C; 5-METHYL-3'-DU CEP; (2R,3R,5S)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5-Me-3'-dU-2'-phosphoramidite; 3′-dT-CE Phosphoramidite; 5’-O-(4,4-Dimethoxytrityl)-3’-deoxy-5-methyl uridine-2’-CED-phosphoramidite; 3′-Deoxy-5′-O-DMT-5-methyluridine 2′-CE phosphoramidite; 3'-Deoxy-5'-O-DMT-5-methyluridine2'-Chosphoramidite

物化性质

• 分子式: C₄₀H₄₉N₄O₈P
• 分子量: 744.81
• 精确质量: 744.32900
• PSA: 150.86000
• LogP: 6.81958

生物活性

• 描述: 5-Me-3'-dU-2'-磷脒是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

合成路线

124482-92-4 143653-61-6 ~64% 142103-12-6

文献：Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

102691-36-1 143653-61-6 ~80% 142103-12-6

文献：Kumar, Anil; Katti, Seturam B.; Madhusudanan, Kunnath P. Nucleosides and Nucleotides, 1997 , vol. 16, # 1-2 p. 11 - 22

4613-71-2 ~% 142103-12-6

文献：Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

143653-60-5 ~% 142103-12-6

文献：Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

7288-28-0 ~% 142103-12-6

文献：Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

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