144143-96-4

• 常用中文名：甲磺酸依普罗沙坦
• 常用英文名：Eprosartan mesylate
• CAS号：144143-96-4
• 分子式：C₂₄H₂₈N₂O₇S₂
• 分子量：520.618
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) RAAS 拮抗剂
• 发布时间：2018-03-14 08:00:00
• 更新时间：2026-07-03 16:49:19
• Eprosartan是非肽类血管紧张素II受体拮抗剂,在鼠和人肾上腺皮质膜中的IC50分别为9.2和3.9 nM。

名称

• 中文名: 甲磺酸依普罗沙坦
• 英文名: eprosartan methanesulfonate
• 中文别名: 抑制剂rostan mesylate; 甲磺酸依普沙坦; 甲磺酸依普罗沙坦,10 MM DMSO 溶液; 依普沙坦甲磺酸盐; 莱克多巴胺; (E)-4-((2-丁基-5-(2-羧基-3-(噻吩-2-基)丙-1-烯-1-基)-1H-咪唑-1-基)甲基)苯甲酸甲磺酸盐; 依普沙坦甲磺酸; rostan Mesylate :甲磺酸依普罗沙坦; 4-[[2-丁基-5-(2-甲酰基-3-噻吩-2-基-丙烯-1-基)-咪唑-1-基]甲基]苯甲酸甲磺酸盐; 马来酸依普沙坦; 甲磺酸依普罗沙坦 标准品; 4-[[2-丁基-5-(2-羧基-3-噻吩-2-基-丙烯-1-基)-咪唑-1-基]甲基]苯甲酸甲磺酸盐
• 英文别名: rostan Mesylate, 10 mM in DMSO; rostan Mesylate ((E)-2-Butyl-1-(p-cboxybenzyl)-alpha-2-thenylimidazole-5-acrylic acid, monome; acide 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophén-2-ylprop-1-én-1-yl]-1H-imidazol-1-yl}méthyl)benzoïque - acide méthanesulfonique (1:1); 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-, methanesulfonate (1:1); (E)-4-((2-butyl-5-(2-cboxy-3-(thiophen-2-yl)prop-1-enyl)-1H-imidazol-1-yl)methyl)benzoic acid; (E)-3-[2-Butyl-1-[(4-cboxyphenyl)methyl]-imidazol-5-yl]-2-(2-thienyl methyl)-2-propenoic acid monomethanesulfonate; 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αZ)-, methanesulfonate (1:1); Sunitinib and its interMediate; Monomethanesulfonate; 4-({2-butyl-5-[(1E)-2-cboxy-2-(thiophen-2-ylMethyl)eth-1-en-1-yl]-1H-iMidazol-1-yl}Methyl)benzoic acid; rostan mesylate, >=; (αE)-α-[[2-Butyl-1-[(4-cboxyphenyl)Methyl]-1H-iMidazol-5-yl]Methylene]-2-thiophenropanoic Acid MonoMethanesulfonate; rostan mesylate //BP; (E)-4-((2-Butyl-5-(2-cboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-imidazol-1-yl)methyl)benzoic acid compound with methanesulfonic acid (1:1); MFCD08141807; (E)-4-((2-Butyl-5-(2-cboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-imidazol-1-yl)methyl)benzoic acid methanesulfonic acid salt; rostan Myslate; rostan MesylateQ: What is rostan Mesylate Q: What is the CAS Number of rostan Mesylate Q: What is the storage condition of rostan Mesylate Q: What e the applications of rostan Mesylate; rostan Mesylate (SKF-108566J); (E)-α-[[2-Butyl-1-[(4-cboxyphenyl)Methyl]-1H-iMidazol-5-yl]Methylene]-2-thiophenropanoic Acid Methanesulfonate; rostan Mesylate (50 mg) ((E)-2-Butyl-1-(p-cboxybenzyl)-alpha-2-thenylimidazole-5-acrylic acid, monomethanesulfonate); Eprosartan (mesylate); (αE)-α-[[2-butyl-1-[(4-cboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-Thiophenropanoic acid methanesulfonate (1:1); 4-[[2-butyl-5-(2-cboxy-3-thiophen-2-yl-prop-1-enyl)-imidazol-1-yl]methyl]benzoic acid mesylate; ROSTAN MESYLATE; Eprosartan Monomethanesulfonate SKF-108566J Teveten; 2-Thiophenropanoic acid, α-[[2-butyl-1-[(4-cboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-, methanesulfonate (1:1); rostanMesylate>; 4-({2-Butyl-5-[(1Z)-2-carboxy-3-(2-thienyl)-1-propen-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1); 4-({2-Butyl-5-[(1E)-2-carboxy-3-(2-thienyl)-1-propen-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1); ostan mesylate; 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid,methanesulfonic acid; rostan Methanesulfonate; 4-({2-Butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzolcarbonsäure-methansulfonsäure(1:1); rostan Monomethanesulfonate; 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate; 4-({2-butyl-5-[(1E)-2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1)

物化性质

• 密度: 1.26 g/cm3
• 沸点: 660.6ºC
• 熔点: 248 °C
• 分子式: C₂₄H₂₈N₂O₇S₂
• 分子量: 520.618
• 闪点: 353.3ºC
• 精确质量: 520.133789
• PSA: 183.41000
• LogP: 5.32920
• 外观性状: 一种白色至灰白色粉末
• 蒸汽压: 2.37E-18mmHg at 25°C
• 储存条件: room temp
• 水溶解性: 水溶性：不溶；易溶于：乙醇

生物活性

• 描述: Eprosartan是非肽类血管紧张素II受体拮抗剂,在鼠和人肾上腺皮质膜中的IC50分别为9.2和3.9 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Qian, J.J., et al., Eprosartan mesylate, an angiotensin II receptor antagonist. Acta Crystallogr Sect E Struct Rep Online, 2011. 67(Pt 4): p. o770-1.

  [2]. Edwards, R.M., et al., Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther, 1992. 260(1): p. 175-81.

  [3]. Conter, H.S., D.W. McKay, and R.J. Reiz, Eprosartan mesylate effectively reduces systolic and diastolic blood pressure in a Canadian primary care setting. Can J Cardiol, 2004. 20 Suppl C: p. 6C-10C.

  [4]. Punzi, H.A. and C.F. Punzi, Once-daily eprosartan mesylate in the treatment of elderly patients with isolated systolic hypertension: data from a 13-week double-blind, placebo-controlled, parallel, multicenter study. J Hum Hypertens, 2004. 18(9): p. 655-61

  [5]. Martynov, M., et al., [Eprosartan mesylate in controlling of blood pressure in patients with ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova, 2002. 102(4): p. 26-30.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%