甲磺酸依普罗沙坦

• 常用名: 甲磺酸依普罗沙坦
• 英文名: Eprosartan mesylate
• CAS号: 144143-96-4
• 分子量: 520.618
• 密度: 1.26 g/cm3
• 沸点: 660.6ºC
• 分子式: C₂₄H₂₈N₂O₇S₂
• 熔点: 248 °C
• 闪点: 353.3ºC
• 符号: GHS07
• 信号词: Warning

甲磺酸依普罗沙坦用途

Eprosartan是非肽类血管紧张素II受体拮抗剂,在鼠和人肾上腺皮质膜中的IC50分别为9.2和3.9 nM。

甲磺酸依普罗沙坦名称

• 中文名: 甲磺酸依普罗沙坦
• 英文名: eprosartan methanesulfonate
• 中文别名: 莱克多巴胺 | 4-[[2-丁基-5-(2-甲酰基-3-噻吩-2-基-丙烯-1-基)-咪唑-1-基]甲基]苯甲酸甲磺酸盐

甲磺酸依普罗沙坦生物活性

• 描述: Eprosartan是非肽类血管紧张素II受体拮抗剂,在鼠和人肾上腺皮质膜中的IC50分别为9.2和3.9 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Qian, J.J., et al., Eprosartan mesylate, an angiotensin II receptor antagonist. Acta Crystallogr Sect E Struct Rep Online, 2011. 67(Pt 4): p. o770-1.

  [2]. Edwards, R.M., et al., Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther, 1992. 260(1): p. 175-81.

  [3]. Conter, H.S., D.W. McKay, and R.J. Reiz, Eprosartan mesylate effectively reduces systolic and diastolic blood pressure in a Canadian primary care setting. Can J Cardiol, 2004. 20 Suppl C: p. 6C-10C.

  [4]. Punzi, H.A. and C.F. Punzi, Once-daily eprosartan mesylate in the treatment of elderly patients with isolated systolic hypertension: data from a 13-week double-blind, placebo-controlled, parallel, multicenter study. J Hum Hypertens, 2004. 18(9): p. 655-61

  [5]. Martynov, M., et al., [Eprosartan mesylate in controlling of blood pressure in patients with ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova, 2002. 102(4): p. 26-30.

甲磺酸依普罗沙坦物理化学性质

• 密度: 1.26 g/cm3
• 沸点: 660.6ºC
• 熔点: 248 °C
• 分子式: C₂₄H₂₈N₂O₇S₂
• 分子量: 520.618
• 闪点: 353.3ºC
• 精确质量: 520.133789
• PSA: 183.41000
• LogP: 5.32920
• InChIKey: DJSLTDBPKHORNY-XMMWENQYSA-N
• SMILES: CCCCc1ncc(C=C(Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1.CS(=O)(=O)O
• 外观性状: 一种白色至灰白色粉末
• 蒸汽压: 2.37E-18mmHg at 25°C
• 储存条件: room temp
• 水溶解性: 水溶性：不溶；易溶于：乙醇

甲磺酸依普罗沙坦安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

甲磺酸依普罗沙坦海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

甲磺酸依普罗沙坦靶点实验

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实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary 来源：824 External Id：P53MS482

实验名称：p53 small molecule agonists, cell-based qHTS assay 来源：824 External Id：P53344

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS233

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ... 来源：824 靶标：N/A External Id：P53MS837

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS898

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甲磺酸依普罗沙坦英文别名

• 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid,methanesulfonic acid
• 4-({2-Butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzolcarbonsäure-methansulfonsäure(1:1)
• acide 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophén-2-ylprop-1-én-1-yl]-1H-imidazol-1-yl}méthyl)benzoïque - acide méthanesulfonique (1:1)
• MFCD08141807
• 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-, methanesulfonate (1:1)
• Eprosartan mesylate
• 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate
• 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αZ)-, methanesulfonate (1:1)
• Eprosartan Monomethanesulfonate SKF-108566J Teveten
• 4-({2-Butyl-5-[(1Z)-2-carboxy-3-(2-thienyl)-1-propen-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1)
• 4-({2-Butyl-5-[(1E)-2-carboxy-3-(2-thienyl)-1-propen-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1)
• 4-({2-butyl-5-[(1E)-2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1)
• Eprosartan (mesylate)