70-30-4

70-30-4结构式

常用中文名：六氯酚
常用英文名：Hexachlorophene
CAS号：70-30-4
分子式：C₁₃H₆Cl₆O₂
分子量：406.904
相关类别：原料药人工合成抗感染类药消毒防腐药
发布时间：2018-03-11 08:00:00
更新时间：2024-01-07 10:04:30
Hexachlorophene(Hexachlorofen)被研究证明是KCNQ1/KCNE1钾离子通道激动剂,EC50值为4.61uM,此外也是Wnt/beta-catenin信号通路抑制剂。

中文名	灭菌酚
英文名	hexachlorophene
中文别名	六氯芬六氯酚 2,2'-亚甲基双(3,4,6-三氯苯酚) 双(3,5,6-三氯-2-羟基苯)甲烷菌蟥酚
英文别名	2,2'-méthanediylbis(3,4,6-trichlorophénol) Germa-Medica 2,2'-Methandiylbis(3,4,6-trichlorbenzolol) Phenol, 2,2'-methylenebis[3,4,6-trichloro- Nabac 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol hexachlorophene Compound G 11 EINECS 200-733-8 HCP MFCD00002171 2,2-Methylenebis(3,4,6-Trichlorophenol) 2,2'-Methylenebis(3,4,6-trichlorophenol) Trichlorophene

描述	Hexachlorophene(Hexachlorofen)被研究证明是KCNQ1/KCNE1钾离子通道激动剂,EC50值为4.61uM,此外也是Wnt/beta-catenin信号通路抑制剂。
相关类别	信号通路 >> 跨膜转运 >> 钾通道信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号研究领域 >> 其他
参考文献	[1]. Zheng Y, et al. Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. PLoS One. 2012;7(12):e51820. [2]. Park S, et al. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol. 2006 Sep;70(3):960-6. [3]. Heath RJ, et al. Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem. 2000 Feb 18;275(7):4654-9.

密度	1.7±0.1 g/cm3
沸点	470.9±40.0 °C at 760 mmHg
熔点	163-165 °C(lit.)
分子式	C₁₃H₆Cl₆O₂
分子量	406.904
闪点	238.6±27.3 °C
精确质量	403.849884
PSA	40.46000
LogP	7.20
外观性状	灰白色至紫色粉末
蒸汽压	0.0±1.2 mmHg at 25°C
折射率	1.670
储存条件	库房通风低温干燥; 与食品原料分开储运
稳定性	1.白色或微带黄色结晶性粉未。熔点164-165℃。 2.溶于醇、醚、丙酮、氯仿、丙二醇、聚乙二醇、橄榄油、棉子油和稀碱液，实际不溶于水。无气味或微带苯酚气味。
分子结构	1、摩尔折射率：88.70 2、摩尔体积（cm³/mol）：237.3 3、等张比容（90.2K）：663.5 4、表面张力（dyne/cm）：61.0 5、极化率（10^-24cm³）：35.16
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:2 4.可旋转化学键数量:2 5.互变异构体数量:5 6.拓扑分子极性表面积40.5 7.重原子数量:21 8.表面电荷:0 9.复杂度:328 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色或浅黄色结晶性自由流动粉末，无味或略带苯酚气味。 2. 密度（g/mL,20℃）：不确定 3. 相对蒸汽密度（g/mL,空气=1）：不确定 4. 熔点（ºC）：164～167 5. 沸点（ºC）：不确定 6. 折射率：不确定 7. 闪点（ºC）：不确定 8. 比旋光度（ºC）：不确定 9. 自燃点或引燃温度（ºC）不确定 10. 蒸气压（kPa,25ºC）：不确定 11. 饱和蒸气压（kPa,60ºC）：不确定 12. 燃烧热（KJ/mol）：不确定 13. 临界温度（ºC）：不确定 14. 临界压力（KPa）：不确定 15. 油水（辛醇/水）分配系数的对数值：不确定 16. 爆炸上限（%,V/V）：不确定 17. 爆炸下限（%,V/V）：不确定 18. 溶解性：溶于醇、醚、丙酮、氯仿、丙二醇、橄榄油、棉籽油和稀碱液，不溶于水。

第一部分：化学品名称

化学品中文名称：	双(3，5，6-三氯-2-羟基苯)甲烷；2，2′-亚甲基-双(3，4，6-三氯苯酚)
化学品英文名称：	Hexachlorophene；2，2′-Methylene bis(3，4，6-trichlorophenol)
中文俗名或商品名：
Synonyms：
CAS No.：	70-30-4
分子式：	C₁₃H₆Cl₆O₂
分子量：	406.89

第二部分：成分/组成信息

纯化学品混合物

化学品名称：双(3，5，6-三氯-2-羟基苯)甲烷；2，2′-亚甲基-双(3，4，6-三氯苯酚)

有害物成分

含量

CAS No.

第三部分：危险性概述

危险性类别：	第6．1类毒害品
侵入途径：	吸入食入经皮吸收
健康危害：	对人体有毒。对眼睛、皮肤、粘膜有刺激作用，可损伤角膜。
环境危害：	对环境有危害。
燃爆危险：	本品可燃，有毒，具刺激性。

第四部分：急救措施

皮肤接触：	用肥皂水及清水彻底冲洗。就医。
眼睛接触：	拉开眼睑，用流动清水冲洗15分钟。就医。
吸入：	脱离现场至空气新鲜处。就医。
食入：	误服者，饮适量温水，催吐。就医。

第五部分：消防措施

危险特性：	遇明火、高热可燃。受高热分解，放出有毒的烟气。
有害燃烧产物：	一氧化碳、二氧化碳、氯化氢。
灭火方法及灭火剂：	消防人员须佩戴防毒面具、穿全身消防服，在上风向灭火。灭火剂：雾状水、抗溶性泡沫、二氧化碳、干粉。
消防员的个体防护：
禁止使用的灭火剂：
闪点(℃)：
自燃温度(℃)：
爆炸下限[%(V/V)]：
爆炸上限[%(V/V)]：
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：

第六部分：泄漏应急处理

应急处理：

隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，用砂土吸收，铲入提桶，倒至空旷地方深埋。被污染地面用肥皂或洗涤剂刷洗，经稀释的污水放入废水系统。如大量泄漏，收集回收或无害处理后废弃。

第七部分：操作处置与储存

操作注意事项：

密闭操作，局部排风。防止粉尘释放到车间空气中。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防尘口罩，戴化学安全防护眼镜，穿防毒物渗透工作服，戴橡胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。避免产生粉尘。避免与氧化剂接触。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。

储存注意事项：

储存于阴凉、通风的库房。远离火种、热源。防止阳光直射。包装密封。应与氧化剂、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。

第八部分：接触控制/个体防护

最高容许浓度：	中国 MAC：未制订标准前苏联 MAC：未制订标准美国TLV—TWA：未制订标准
监测方法：
工程控制：	严加密闭，提供充分的局部排风。尽可能机械化、自动化。
呼吸系统防护：	可能接触其粉尘时，佩戴防毒口罩。必要时佩戴自给式呼吸器。
眼睛防护：	戴化学安全防护眼镜。
身体防护：	穿相应的防护服。
手防护：	戴防化学品手套。
其他防护：	工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。特别注意眼和呼吸道的防护。

第九部分：理化特性

外观与性状：	白色或浅褐色粉末。
pH：
熔点(℃)：	164～165
沸点(℃)：
相对密度(水=1)：
相对蒸气密度(空气=1)：
饱和蒸气压(kPa)：
燃烧热(kJ/mol)：
临界温度(℃)：
临界压力(MPa)：
辛醇/水分配系数的对数值：
闪点(℃)：
引燃温度(℃)：
爆炸上限%(V/V)：
爆炸下限%(V/V)：
分子式：	C₁₃H₆Cl₆O₂
分子量：	406.89
蒸发速率：
粘性：
溶解性：	不溶于水，溶于醇、丙酮、乙醚、氯仿、丙二醇、油类、稀碱液。
主要用途：	用作防霉抑菌剂。

第十部分：稳定性和反应活性

稳定性：	在常温常压下稳定
禁配物：	强氧化剂。
避免接触的条件：
聚合危害：	不能出现
分解产物：	一氧化碳、二氧化碳、氯化氢。

第十一部分：毒理学资料

急性毒性：	LD50：56mg／kg(大鼠经口)；1840mg／kg(兔经皮) LC50：
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：	人经皮： 3mg/3天（连续），轻度刺激。家兔经皮：1250μg/24小时，轻度刺激。
致敏性：
致突变性：
致畸性：
致癌性：

第十二部分：生态学资料

生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：

第十三部分：废弃处置

废弃物性质：
废弃处置方法：	建议用焚烧法处置。在能利用的地方重复使用容器或在规定场所掩埋。
废弃注意事项：

第十四部分：运输信息

危险货物编号：	61708
UN编号：	2875
包装标志：
包装类别：	Ⅲ
包装方法：	螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶（罐）外普通木箱；螺纹口玻璃瓶、塑料瓶或镀锡薄钢板桶（罐）外满底板花格箱、纤维板箱或胶合板箱。
运输注意事项：	储存于阴凉、通风仓间内。远离火种、热源。保持容器密封。专人保管。应与氧化剂、食用化工原料分开存放。不能与粮食、食物、种子、饲料、各种日用品混装、混运。操作现场不得吸烟、饮水、进食。搬运时要轻装轻卸，防
RETCS号：
IMDG规则页码：

第十五部分：法规信息

国内化学品安全管理法规：

化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品。

国际化学品安全管理法规：

第十六部分：其他信息

参考文献：	1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间：	年月日
填表部门：
数据审核单位：
修改说明：
其他信息：	6
MSDS修改日期：	年月日

毒理学数据:

口服-大鼠 LD50: 56 毫克/公斤; 口服-小鼠 LC50: 67 毫克/公斤

皮肤-兔子 0.03 毫克轻度; 眼睛-兔子 1500 毫克/24小时中度

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM0700000

CHEMICAL NAME :: Phenol, 2,2'-methylenebis(3,4,6-trichloro-

CAS REGISTRY NUMBER :: 70-30-4

BEILSTEIN REFERENCE NO. :: 2064407

LAST UPDATED :: 199710

DATA ITEMS CITED :: 68

MOLECULAR FORMULA :: C13-H6-Cl6-O2

MOLECULAR WEIGHT :: 406.89

WISWESSER LINE NOTATION :: QR BG DG EG F1R BQ CG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 25,113,1974

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Mammal - dog

REFERENCE :: AAOPAF AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. Volume(issue)/page/year: 53,817,1955

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 25,113,1974

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 25,113,1974

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AAOPAF AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. Volume(issue)/page/year: 53,817,1955

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 25,113,1974

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 25,113,1974 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 257 mg/kg/7D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Gastrointestinal - hypermotility, diarrhea Vascular - shock

REFERENCE :: AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 111,333,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 1,737,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Cardiac - cardiomyopathy including infarction Gastrointestinal - nausea or vomiting

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 181,587,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,332,1973

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 340 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(8),25,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1840 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 24,239,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7650 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 38,64,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,332,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes

REFERENCE :: CMJOAP Chinese Medical Journal (Peking, 1932-1966). (Peking, Peop. Rep. China) V.46-85, 1932-66. For publisher information, see CHHTAT. Volume(issue)/page/year: 82,691,1963

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(8),25,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZMMPAO Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie. (Stuttgart, Fed. Rep. Ger.) V.217-245, 1971-79. Volume(issue)/page/year: 234,110,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VEARA6 Veterinarski Arhiv. Veterinary Archives. (Jugoslovenska Knjiga, 36, YU-11001, Belgrade, Yugoslavia) V.1- 1931- Volume(issue)/page/year: 35,35,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Blood - change in clotting factors

REFERENCE :: SURGAZ Surgery. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1937- Volume(issue)/page/year: 24,542,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 40690 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 20,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 8500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 20,173,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,742,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,210,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 320,426,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2730 mg/kg/13W-C

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle weakness

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,591,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1669 mg/kg/16W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 24,239,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/kg/14W-C

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Related to Chronic Data - death

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,114,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 360 mg/kg/9D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Brain and Coverings - changes in brain weight Sense Organs and Special Senses (Eye) - optic nerve neuropathy

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,519,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 mg/kg/50D-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Behavioral - alteration of operant conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 9,331,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1440 mg/kg/30D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,375,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg/7D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Autonomic Nervous System - other (direct) parasympathomimetic Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 16,631,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 58800 mg/kg/12W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 5,77,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1500 mg/kg/30D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 13,317,1994 ** TUMORIGENIC DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33500 ug/m3/52W

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 33(1),62,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 435 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,421,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 137 mg/kg

SEX/DURATION :: male 14 week(s) pre-mating female 14 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 23,866,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 7-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 5,264,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 315 mg/kg

SEX/DURATION :: male 63 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 5,405,1980

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 33500 ug/m3/24H

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(8),25,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 80 mg/kg

SEX/DURATION :: female 8-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 28,43,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 300 mg/kg

SEX/DURATION :: female 8-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 28,43,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 3150 ug/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 31500 ug/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 75 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: PPASAK Proceedings of the Pennsylvania Academy of Science. (Pennsylvania Academy of Science, c/o Treasurer, Gannon College, Perry Sg., Erie, PA 16501) V.1- 1924/26- Volume(issue)/page/year: 49,110,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 189 mg/kg

SEX/DURATION :: male 63 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 5,405,1980 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,241,1979 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,241,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 13,439,1973 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,119,1971 TOXICOLOGY REVIEW JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 1,263,1975 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 5,100,1974 TOXICOLOGY REVIEW PRTODI "Progress in Toxicology," Zbinden, G., New York, Springer-Verlag, 1973 Volume(issue)/page/year: 1,56,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 36710 No. of Facilities: 2049 (estimated) No. of Industries: 18 No. of Occupations: 33 No. of Employees: 88875 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 36710 No. of Facilities: 3480 (estimated) No. of Industries: 11 No. of Occupations: 41 No. of Employees: 403543 (estimated) No. of Female Employees: 351670 (estimated)

符号	GHS02, GHS06, GHS08, GHS09
信号词	Danger
危害声明	H225-H301 + H311 + H331-H370-H411
警示性声明	P210-P260-P273-P280-P301 + P310-P311
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T: Toxic;N: Dangerous for the environment;
风险声明 (欧洲)	R24/25;R50/53
安全声明 (欧洲)	S20-S37-S45-S60-S61-S36/37
危险品运输编码	UN 2875 6.1/PG 3
WGK德国	3
RTECS号	SM0700000
包装等级	III
危险类别	6.1(b)
海关编码	2907299010

上游产品 3
50-00-0 95-95-4 7664-93-9
下游产品 1
2467-02-9

1.由2,4,5-三氯酚与甲醛或聚甲醛反应而得。将三氯酚、聚甲醛和硫酸搅拌混合，升温至75℃，反应液由稀薄变得稠厚，又立即由稠厚变为稀薄，将反应液倒入大量冰水中。过滤，滤饼用热水洗至中性，用稀碱溶解后加热至90℃，加入保险粉和活性炭，脱色30min。过滤，滤液加盐酸调节pH至2-3，冷至50℃以下，甩滤，滤饼用水洗涤，于80℃干燥，得六氯酚粗品。粗品经重结晶、精制即得成品。收率66%。

另一种操作方法是使反应在溶剂二氯乙烷中进行，即将70g三氯酚、125ml二氯乙烷和32g20%发烟硫酸混合，加热至70-88℃，在1h内边搅拌边加入5.8g聚甲醛。全部加完后，回流1.5h，慢慢加入125ml二氯乙烷。停止搅拌，从底部将重硫酸层分离，用62ml二氯乙烷分两次提取硫酸层。将提取液与反应液分出的二氯乙烷层合并，加3g脱色炭脱色，然后在80℃过滤，加125ml水后，用水蒸汽蒸馏，将馏出物中悬浮的生成物滤出，干燥，得67.5-70g六氯酚。

海关编码	2907299010
中文概述	2907299010 毒菌酚退税率:0.0% 监管条件:S(进出口农药登记证明)
申报要素	品名, 成分含量, 用途
监管条件	S.进出口农药登记证明
Summary	2907299010 6,6'-methylenebis(2,4,5-trichlorophenol)

70-30-4	16893-14-4
19567-78-3	38380-07-3
155911-16-3	13520-78-0
67471-27-6	17116-10-8
13283-01-7	1307-80-8