57436-38-1

57436-38-1结构式

中文名	3,6,9,12,15,18,21-七氧杂二十三烷-1,23-二基二(4-甲基苯磺酸酯)
英文名	2-[2-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
中文别名	八乙二醇二对甲苯磺酸酯甲苯磺酸酯-九聚乙二醇-甲苯磺酸酯对甲苯磺酸酯-八乙二醇-对甲苯磺酸酯
英文别名	Tos-PEG9-Tos 1,23-bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatricosane Tos-PEG8-Tos/3,6,9,12,15,18,21-Htaoxatricosane-1,23-diol, 1,23-bis(4-methylbenzenesulfonate) 3,6,9,12,15,18,21-Htaoxatricosane-1,23-diol, 1,23-bis(4-methylbenzenesulfonate) TSO-PEG8-OTS 3,6,9,12,15,18,21-Htaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate) 3,6,9,12,15,18,21-Htaoxatricosane-1,23-diol,bis(4-methylbenzenesulfonate) Octaethylene glycol di(p-toluenesulfonate) 23-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12,15,18,21-htaoxatricosan-1-yl 4-methylbenzene-1-sulfonate 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate) 1,24-bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatetracosane Octaethylene glycol ditosylate

描述	Tos-PEG8-Tos 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
相关类别	研究领域 >> 癌症信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
靶点	PEGs
体外研究	PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
参考文献	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

5117-19-1

98-59-9

~99%

57436-38-1

文献：Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873

37860-51-8

57436-38-1

文献：Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873

112-60-7

57436-38-1

文献：Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873

144270-98-4

57436-38-1

文献：Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873