132414-02-9

• 常用中文名：阿洛司琼 (盐酸 (1:X))
• 常用英文名：Alosetron (Hydrochloride(1:X))
• CAS号：132414-02-9
• 分子式：C₁₇H₁₈N₄O_.xHCl
• 分子量：330.81200
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2017-01-27 13:51:00
• 更新时间：2024-01-07 17:18:42
• Alosetron是5-HT3受体拮抗剂,可作用于肠易激综合征。

名称

• 中文名: 阿洛司琼(盐酸盐(1：X))
• 英文名: 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one,hydrochloride
• 英文别名: UNII-2F5R1A46YW; alosetron monohydrochloride; Alosetron HCl; Alosetron (Hydrochloride(1:X))

物化性质

• 分子式: C₁₇H₁₈N₄O_.xHCl
• 分子量: 330.81200
• 精确质量: 330.12500
• PSA: 53.92000
• LogP: 3.14820
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Alosetron是5-HT3受体拮抗剂,可作用于肠易激综合征。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Cremonini F, Nicandro JP, Atkinson V, Shringarpure R, Chuang E, Lembo A.Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS.Aliment Pharmacol Ther. 2012 Sep;36(5):437-48. doi: 10.1111/j.1365-2036.2012.05208.x.

  [2]. Nicandro JP, Shin P, Chuang E.Evaluation of treatment continuation with alosetron by IBS-D severity criteria.Curr Med Res Opin. 2012 Mar;28(3):449-56.

  [3]. Bleser S.Alosetron for severe diarrhea-predominant irritable bowel syndrome: improving patient outcomes.Curr Med Res Opin. 2011 Mar;27(3):503-12.

  [4]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74

  [5]. Alosetron: an effective treatment for diarrhea-predominant irritable bowel syndrome By Harris, Lucinda A.; Chang, Lin From Women's Health (2007), 3(1), 15-27