667463-95-8

• 常用中文名：(2'Z,3'E)-6-溴-1-甲基靛红3'-肟(MeBIO)
• 常用英文名：MeBIO
• CAS号：667463-95-8
• 分子式：C₁₇H₁₂BrN₃O₂
• 分子量：370.20
• 相关类别： 信号通路 细胞周期/DNA损伤 CDK
• 发布时间：2016-02-10 14:42:16
• 更新时间：2024-01-25 00:31:13
• MeBIO是一种有效的AhR(芳香烃受体)激动剂,IC50分别为44μM(GSK-3)和55μM(CDK1/细胞周期蛋白B)。MeBIO对GSK-3β无活性[1]。

名称

• 中文名: (2'Z,3'E)-6-溴-1-甲基靛红3'-肟(MeBIO)
• 英文名: 6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1-methylindol-2-one
• 英文别名: methyl-6BIO; 6-bromo-1-methylindirubin-3'-oxime; IN1310

物化性质

• 分子式: C₁₇H₁₂BrN₃O₂
• 分子量: 370.20
• 精确质量: 369.01100
• PSA: 64.93000
• LogP: 1.44850
• 储存条件: -20°C

生物活性

• 描述: MeBIO是一种有效的AhR(芳香烃受体)激动剂,IC50分别为44μM(GSK-3)和55μM(CDK1/细胞周期蛋白B)。MeBIO对GSK-3β无活性[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GSK-3
  研究领域 >> 其他
  信号通路 >> 免疫及炎症 >> 芳基烃受体
  信号通路 >> 细胞周期/DNA损伤 >> CDK
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
• 靶点:

  GSK-3:44 μM (IC50)

  Cdk1/cyclin B:55 μM (IC50)

  Cdk5/p25:>100 μM (IC50)

• 参考文献:

  [1]. Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66.

合成路线

667463-98-1 ~% 667463-95-8

文献：Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946

6326-79-0 ~% 667463-95-8

文献：Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946

667463-64-1 ~% 667463-95-8

文献：Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946

591-19-5 ~% 667463-95-8

文献：Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946

65971-74-6 ~% 667463-95-8

文献：Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946

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