65604-80-0

• 常用中文名：麦冬皂苷D'
• 常用英文名：Ophiopogonin D'
• CAS号：65604-80-0
• 分子式：C₄₄H₇₀O₁₆
• 分子量：855.017
• 相关类别： 信号通路 细胞周期/DNA损伤 抗衰老酶
• 发布时间：2018-05-10 08:00:00
• 更新时间：2026-07-01 20:47:44
• Ophiopogonin D' 是从麦冬 (Ophiopogon japonicus) 的块茎中分离的,是一种罕见的天然存在的 C29 甾体糖苷。Ophiopogonin D' 针对两种人肿瘤细胞系 MG-63 和 SNU387 的有细胞毒活性,IC50 分别为 3.09 μM 和 3.63 μM。Ophiopogonin D' 以剂量依赖方式激活 SIRT1。

名称

• 中文名: 麦冬皂苷D
• 英文名: (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-β-D-glucopyranoside
• 中文别名: (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-羟基-6-(羟甲基)-2-(((4S,5'R,6,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-四甲基-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-二十氢螺[萘并[2',1':4,5]茚并[2,1-b]呋喃-10,2'-吡喃]-4-基)氧基)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol; 麦冬皂苷 D',10 MM DMSO 溶液; 麦冬皂苷 D'; 麦冬皂苷D'Ophiopogonin D'; 麦冬皂苷D 分析标准品
• 英文别名: β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]; (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-Hydroxy-6-(hydroxymethyl)-2-(((4S,5'R,6,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol; Desacetylophiopogonin B'; (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->; Ophiopogonin D''; 3)]-β-D-glucopyranoside; Ophiopogonin D`; Ophiopogonin D'', 10 mM in DMSO; Diosgenin 3-O-[alpha-L-rhamnopyranosyl-][beta-D-xylopyranosyl-]-beta-D-glucopyranoside; Sirtuin,inhibit,Ophiopogonin D',Inhibitor; (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1-)-[β-D-xylopyranosyl-(1-)]-β-D-glucopyranoside; (3beta,25R)-spirost-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₄₄H₇₀O₁₆
• 分子量: 855.017
• 精确质量: 854.466370
• PSA: 235.68000
• LogP: 6.69
• 折射率: 1.618
• 储存条件: 2-8°C

生物活性

• 描述: Ophiopogonin D' 是从麦冬 (Ophiopogon japonicus) 的块茎中分离的,是一种罕见的天然存在的 C29 甾体糖苷。Ophiopogonin D' 针对两种人肿瘤细胞系 MG-63 和 SNU387 的有细胞毒活性,IC50 分别为 3.09 μM 和 3.63 μM。Ophiopogonin D' 以剂量依赖方式激活 SIRT1。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
• 靶点:

  SIRT1

• 参考文献:

  [1]. Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132.

  [2]. Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9.

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