65604-80-0

65604-80-0 structure

Name: Ophiopogonin D'
Chemical Name: (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-β-D-glucopyranoside
CAS Number: 65604-80-0
Molecular Formula: C₄₄H₇₀O₁₆
Molecular Weight: 855.017
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2018-05-10 08:00:00
Modify Date: 2026-07-01 20:47:44
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC50s of 3.09 μM and 3.63 μM, respectively[1]. Ophiopogonin D' activates SIRT1 in a dose-dependent manner[2].

Name	(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-β-D-glucopyranoside
Synonyms	β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)] (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-Hydroxy-6-(hydroxymethyl)-2-(((4S,5'R,6,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol Desacetylophiopogonin B' (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1-> Ophiopogonin D'' 3)]-β-D-glucopyranoside Ophiopogonin D` Ophiopogonin D'', 10 mM in DMSO Diosgenin 3-O-[alpha-L-rhamnopyranosyl-][beta-D-xylopyranosyl-]-beta-D-glucopyranoside Sirtuin,inhibit,Ophiopogonin D',Inhibitor (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1-)-[β-D-xylopyranosyl-(1-)]-β-D-glucopyranoside (3beta,25R)-spirost-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl

Description	Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC50s of 3.09 μM and 3.63 μM, respectively[1]. Ophiopogonin D' activates SIRT1 in a dose-dependent manner[2].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT1
References	[1]. Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132. [2]. Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9.