中文名 | 氮芥盐酸盐 |
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英文名 | mechlorethamine hydrochloride |
中文别名 |
恩比兴
二氯甲基二乙胺盐酸盐 盐酸氮芥 2-氯-N-(2-氯乙基)-N-甲基乙胺盐酸盐 N-甲基-N-(2-氯乙基)-2-氯乙胺盐酸盐 |
英文别名 |
Ethanamine, 2-chloro-N- (2-chloroethyl)-N-methyl-, hydrochloride
n-lost pliva Mustargen hydrochloride β,β'-Dichlorodiethyl-N-methylamine hydrochloride 2-Chlor-N-(2-chlorethyl)-N-methylethanaminhydrochlorid Methyldi(β-chloroethyl)amine hydrochloride Mechlorethamine HCl Cloramin 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride Nitrogen mustard HCl MFCD00012517 bis(2-chlorolthyl)amine hydrochloride zagreb EINECS 200-246-0 Methylbis(β-chloroethyl)amine hydrochloride c6866 b,b'-Dichlorodiethyl-N-methylamine Hydrochloride chloramin N-Methylbis(β-chlorethyl)amine hydrochloride dimitan Nitrogranulogen erasol antimit dichloren Embichen Bis(2-chloroethyl)methylamine hydrochloride Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, hydrochloride (1:1) Mechlorethamine hydrochloride SK 101 2-chloro-N-(2-chloroéthyl)-N-méthyléthanamine chlorhydrate 2-Chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (1:1) MBA hydrochloride Chlormethine (hydrochloride) |
描述 | Chlormethine盐酸盐是一种发泡剂,对粘膜造成坏死性刺激性破坏。用在霍奇金病和淋巴瘤中抗肿瘤。 |
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相关类别 | |
参考文献 |
密度 | 1.106g/cm3 |
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沸点 | 110.3ºC at 760 mmHg |
熔点 | 108-111 °C(lit.) |
分子式 | C5H12Cl3N |
分子量 | 192.514 |
闪点 | 20.5ºC |
精确质量 | 191.003525 |
PSA | 3.24000 |
LogP | 2.19780 |
外观性状 | 白色结晶粉末 |
折射率 | 1.4689 (24ºC) |
储存条件 | 库房通风低温干燥,与食品原料分开存放 |
稳定性 | Stable. Hygroscopic. |
计算化学 | 1.疏水参数计算参考值(XlogP):无 2.氢键供体数量:1 3.氢键受体数量:1 4.可旋转化学键数量:4 5.互变异构体数量:无 6.拓扑分子极性表面积3.2 7.重原子数量:9 8.表面电荷:0 9.复杂度:43.7 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
更多 | 1.熔点(℃):108-111。. |
Synonym:N-Methylbis(2-chloroethyl)amine hydrochlorid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 26/27/28 33 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed. Danger of cummulative effects.Cancer suspect agent.Hygroscopic. Potential Health Effects The toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice. Inhalation: Remove from exposure to fresh air immediately. Notes to Physician: Treat symptomatically. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Autoignition Temperature: Not available. Flash Point: Not available. NFPA Rating: Not published. Explosion Limits, Lower: Not available. Upper: Not available. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up, then place into a suitable container for disposal. Section 7 - HANDLING and STORAGE Handling: Not available. Storage: Poison room locked. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Wear a NIOSH/MSHA-approved (or equivalent) full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Not available. Appearance: beige Odor: None reported. pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate: Not available. Viscosity: Not available. Boiling Point: @ 760.00mm Hg Freezing/Melting Point: 108.00 - 110.00 deg C Decomposition Temperature: Not available. Solubility: soluble Specific Gravity/Density: Not available. Molecular Formula: C5H11Cl2N.HCl Molecular Weight: 192.52 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Not available. Incompatibilities with Other Materials: Strong oxidizing agents - moisture. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 55-86-7: IA2100000 LD50/LC50: CAS# 55-86-7: Oral, mouse: LD50 = 20 mg/kg; Oral, rabbit: LD50 = 12500 ug/kg; Oral, rat: LD50 = 10 mg/kg. Carcinogenicity: Mechlorethamine hydrochloride, 98% - California: carcinogen NTP: Suspect carcinogen OSHA: Possible Select carcinogen See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION For further information, contact Fisher Scientific. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION CDG/CPL IMO Shipping Name: TEAR GAS SUBSTANCE, SOLID, N.O.S. Hazard Class: 6.1 UN Number: 1693 Packing Group: II IATA Shipping Name: TEAR GAS SUBSTANCE, SOLID, N.O.S.* Hazard Class: 6.1 UN Number: 1693 Packing Group: II RID/ADR Shipping Name: TEAR GAS SUBSTANCE, SOLID, N.O.S. Dangerous Goods Code: 6.1(25B) UN Number: 1693 Canadian TDG No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T+ Risk Phrases: R 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed. R 33 Danger of cummulative effects. Safety Phrases: S 22 Do not inhale dust. S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 55-86-7: Canada None of the chemicals in this product are listed on the DSL/NDSL list. WHMIS: Not available. CAS# 55-86-7 is not listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 55-86-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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符号 |
GHS05, GHS06, GHS08 |
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信号词 | Danger |
危害声明 | H300 + H310-H314-H340-H350-H360D |
警示性声明 | P201-P264-P280-P301 + P310-P302 + P350-P305 + P351 + P338 |
个人防护装备 | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
危害码 (欧洲) | T+:Verytoxic; |
风险声明 (欧洲) | R45;R46;R28;R34;R42/43 |
安全声明 (欧洲) | S53-S36/37/39-S45 |
危险品运输编码 | UN 2811 6.1/PG 2 |
WGK德国 | 3 |
RTECS号 | IA2100000 |
包装等级 | II |
危险类别 | 6.1(a) |
海关编码 | 2921199090 |
上游产品 5 | |
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下游产品 10 | |
海关编码 | 2921199090 |
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中文概述 | 2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |