157283-68-6

• 常用中文名：曲伏前列腺素
• 常用英文名：Travaprost
• CAS号：157283-68-6
• 分子式：C₂₆H₃₅F₃O₆
• 分子量：500.55
• 相关类别： 原料药 激素及调节内分泌功能类药 前列腺素类药
• 发布时间：2018-02-17 08:00:00
• 更新时间：2026-07-01 12:12:26
• Travoprost可作用于青光眼和眼高压。

名称

• 中文名: 曲沃前列素
• 英文名: travoprost
• 中文别名: 曲伏前列素标准品; 曲伏前列素TRAVOPROST; 曲沃前列素(曲伏前列素); (Z)-异丙基 7-((1R,2R,3R,5S)-3,5-二羟基-2-((R,E)-3-羟基-4-(3-(三氟甲基)苯氧基)丁-1-烯-1-基)环戊基)庚-5-烯酸酯; 曲伏前列素,10 MM DMSO 溶液; 曲伏前列素对照品; 抑制剂Travoprost; 曲伏前列素/曲沃前列素; 15(S)-氟丁烯醇异丙酯; 曲伏前列素; 曲沃前列腺素; 甲醇中曲伏前列素溶液标准物质; (E)-7-[(1R,2S,3R,5S)-3,5-二羟基-2-[(E)-3-羟基-4-[3-(三氟甲基)苯氧基]丁-1-烯基]环戊基]庚-5-烯酸异丙醚; 4-氯-7-硝基苯并-2-氧杂-1; 曲沃前列素157-6157-6; (Z)-7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(R,E)-3-羟基-4-[3-三氟甲基苯氧基]-1-丁烯-1-基]环戊基]-5-庚烯酮; 曲沃前列素原料; 曲伏前列素-D4; 3-二唑; 曲伏/曲沃前列腺素
• 英文别名: propan-2-yl (e)-7-[(1r,2s,3r,5s)-3,5-dihydroxy-2-[(e)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]ht-5-enoate; Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(R,E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-htenoate; cGMP Travoprost; Travoprostt; trans-p-Propenylanisole; FLUPROSTENOL ISOPROPYL ESTER; propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]ht-5-enoate; (E)-1-methoxy-4-(prop-1-en-1-yl)benzene; 1-methoxy-4-[(1E)-prop-1-en-1-yl]benzene; (+)-FLUPROSTENOL ISOPROPYL ESTER; Travoprost Impurity 33; trans-4-Propenylanisole; (+)-Fluprostenol isopropyl ester; 1-Methoxy-4-[(1E)-1-propen-1-yl]benzene; Nauli gum; p-Anethole; Isoestragole; trans-Anethol; Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl}cyclopentyl]-5-heptenoate; Travoprost Eye Drops; Trovoprost; Trivoprost; (E)-1-Methoxy-4-(1-propenyl)benzene; Travoprost (For eye drops); Travoprost; ravopros; 15(S)-FLU-IPR; trans-1-(p-Methoxyphenyl)-1-propene; 1-Methoxy-4-(prop-1-en-1-yl)benzene; (E)-1-(4-Methoxyphenyl)propene; (+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER; Travoprost, 10 mM in DMSO; trans-p-Anethole; Travoprost（Fluprostenol Isopropyl Ester）; (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluorométhyl)phénoxy]but-1-én-1-yl}cyclopentyl]hept-5-énoate de 1-méthyléthyle; p-(1-Propenyl)anisole; propan-2-yl 7-[(1R,2S,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]ht-5-enoate; (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-htenoic Acid 1-Methylethyl Ester; trans-1-(p-Methoxyphenyl)propene; Methyl 4-[(1E)-prop-1-en-1-yl]phenyl ether; trans-1-Methoxy-4-(1-propenyl)benzene; 1-methylethyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate; trevostaglandin; Travoprost, (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2; (Z)-Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)ht-5-enoate; 9ALPHA,11ALPHA,15S-TRIHYDROXY-16(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER; Travoprost D7; (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]buten-1-yl][cyclopentyl]ht-5-enoate; Quvoprost/Quvoprost; trans-4-(1-Propenyl)anisole; Travoprost API; MFCD03411995; TravoprostQ: What is Travoprost Q: What is the CAS Number of Travoprost Q: What is the storage condition of Travoprost Q: What e the applications of Travoprost; Travoprost (AL-6221); 15(S)-FLUPROSTENOL ISOPROPYL ESTER; 1-Methylethyl-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluormethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoat; Trivo; AL 6221; Travoprost (COLD SHIPMENT REQUIRED); Travoprost //BP; Anise camphor; TRAVOPROST; (4-isopropyloxcbonylbutyl)dipenhylphosphine oxide; p-1-Propenylanisole; p-propenylanisole; cis-Anethol; (5Z)-isopropyl 7-((1R,2R,3R,5S)-2-((R,E)-4-(3-(trifluoromethyl)phenoxy)-3-hydroxybut-1-enyl)-3,5-dihydroxycyclopentyl)ht-5-enoate; Travoprostum; 5-Htenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z); EINECS 201-001-2; trans-p-Methoxy-β-methylstyrene; (+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2; p-Methoxy-β-methylstyrene; Travatan; Travoprost, >=; FLU-IPR; Travo-Z; Methoxy-4-propenylbenzene; isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)ht-5-enoate; propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]but-1-en-1-yl]cyclopentyl]ht-5-enoate; OIL OF ANISEED; Travoprostintermediates; trans-1-(4-Methoxyphenyl)-1-propene; Travatan Z; 1-Méthoxy-4-[(1E)-1-propèn-1-yl]benzène; Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate; Anethole; (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-htenoic acid 1-methyethyl ester; 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-(5Z)-5-htenoic acid 1-methylethyl ester

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 237.5±9.0 °C at 760 mmHg
• 分子式: C₂₆H₃₅F₃O₆
• 分子量: 500.55
• 闪点: 90.6±0.0 °C
• PSA: 96.22000
• LogP: 3.17
• 外观性状: 无色油状
• 蒸汽压: 0.1±0.5 mmHg at 25°C
• 折射率: 1.545
• 储存条件: −20°C
• 分子结构:

  1、 摩尔折射率：127.52

  2、 摩尔体积（cm³/mol）：401.9

  3、 等张比容（90.2K）：1021.2

  4、 表面张力（dyne/cm）：41.6

  5、 极化率（10-24cm3）：50.55

• 更多:

  1.性状：无色至淡黄色油状物

  2.闪点（ºC）：17

  3.溶解性：极易溶于乙腈、甲醇、辛醇或氯仿，几乎不溶于水

生物活性

• 描述: Travoprost可作用于青光眼和眼高压。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 其他
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/Travoprost

安全

• 危害码 (欧洲): F,Xi
• 风险声明 (欧洲): R11
• 安全声明 (欧洲): S16-S26-S36
• 危险品运输编码: UN 1170 3/PG 2
• WGK德国: 1
• 海关编码: 2918199090

制备

7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(3S)-4-(3-三氟甲基苯氧基)-3-羟基-1E-戊烯基]环戊基]-5Z-庚烯酸和异丙醇
进行酯化，即得产物。

海关

海关编码	2918199090
中文概述	HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%