25507-04-4

• 常用中文名：克林霉素棕榈酸酯盐酸盐
• 常用英文名：Clindamycin palmitate HCl
• CAS号：25507-04-4
• 分子式：C₃₄H₆₄Cl₂N₂O₆S
• 分子量：699.853
• 相关类别： 原料药 抗生素类药物 林可胺类药
• 发布时间：2018-04-20 08:00:00
• 更新时间：2026-07-07 17:20:10
• Clindamycin palmitate hydrochloride 是克林霉素和棕榈酸酯的水溶性盐酸盐,是一种抗菌药物。Clindamycin palmitate hydrochloride 在体外是无活性的,快速体内水解可以将该化合物转化为抗菌活性克林霉素。

名称

• 中文名: 棕榈氯林可霉素盐酸盐
• 英文名: Clindamycin Palmitate Hydrochloride
• 中文别名: 盐酸克林霉素棕榈酯 标准品; 克林霉素棕铝酸脂; 盐酸克林霉素棕榈酸酯; 盐酸克林霉素棕榈酯; 克林霉素 2-棕榈酸盐酸盐; 克林霉素杂质85; 克林霉素棕榈酸酯盐; 克林霉素 2-棕榈酸酯 HCL; 盐酸克林霉素棕榈酸酯 Clindamycin Palmitate Hydrochloride; 克林霉素棕榈酸酯盐酸盐 标准品; 克林霉素棕榈酸酯盐酸盐CLINDAMYCIN PALMITATE HYDROCHLORIDE; 克林霉素杂质64 盐酸盐; 6-(1-甲基-反-4-丙基-L-2-吡咯烷甲酰氨基)-1-硫代-7(S)-氯-6,7,8-三脱氧-L-苏式-Α-D-半乳辛吡喃糖苷-2-棕榈酸酯盐酸盐; CLINDAMYCIN棕榈酸盐盐酸盐; 克林霉素2-棕榈酸盐HCL
• 英文别名: CLINDAMYCIN PALMITATE HYDROCHLORIDE , NON-STERILE, BULK DRUG; Methyl (5R)-5-[(1S,2S)-2-chloro-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-2-O-palmitoyl-1-thio-β-L-arabinopyranoside hydrochloride (1:1); Clindamycin 2-Palmitate HCl; L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-2-O-(1-oxohexadecyl)-1-thio-, hydrochloride (1:1); Clindamycin palmitate hydrochloride //BP; Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-palmitate monohydrochloride; CLINDAMYCIN PALMITATE HYDROCHLORIDE (NON-STERILE DRUG SUBSTANCE); clindamycin2’-palmitatehydrochloride; methyl 7-chloro-6,7,8-trideoxy-2-O-hexadecanoyl-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-L-threo-α-D-galacto-octopyranoside hydrochloride (1:1); CLINDAMYCIN PALMITATE HCL; Methyl (2S-trans)-7-Chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-2-hexadecanoate-L-threo-a-D-galacto-octopyranoside Monohydrochloride; Clindamycin Impurity 85; Clindamycin palmitate hydrochloride; Clindamycin Palmitate HCl 37; Clindmycin; U 25179E; methyl 7-chloro-6,7,8-trideoxy-2-O-hexadecanoyl-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-L-threo-α-D-galacto-octopyranoside hydrochloride; Clindmycin palmitate hydrochloride //BP; (2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)propyl]-4,5-dihydroxy-2-(methylsulfanyl)tetrahydro-2H-pyran-3-yl hexadecanoate hydrochloride; Methyl 7-Chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-a-D-galacto-octopyranoside 2-Palmitate Monohydrochloride; Cleocin Pediatric; Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl] carbonyl]amino]-1-thio-L-threo-α-D-galactooctopyranoside 2-Hexadecanoate Monohydrochloride; L-threo-α-D-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-2-O-(1-oxohexadecyl)-1-thio-, monohydrochloride; hexadécanoate de (2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-({[(2S,4R)-1-méthyl-4-propylpyrrolidin-2-yl]carbonyl}amino)propyl]-4,5-dihydroxy-2-(méthylsulfanyl)tétrahydro-2H-pyran-3-yle chlorhydrate; Methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-2-O-palmitoyl-1-thio-L-threo-α-D-galacto-octopyranoside hydrochloride (1:1); hexadecanoic acid [6-[2-chloro-1-[[(1-methyl-4-propyl-2-pyrrolidinyl)-oxomethyl]amino]propyl]-4,5-dihydroxy-2-(methylthio)-3-oxanyl] ester; Clindamycin Palmitate Hydrochloride G0D334586ug/mg(an); methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- 2-hexadecanoate-L-threo-α-D-galacto-octopyranoside,monohydrochloride; Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-hexadecanoatemonohydrochloride; Clindamycin 2-palmitate hydrochloride; (2R,3R,4S,5R,6R)-6-[(1S,2S)-2-Chlor-1-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)propyl]-4,5-dihydroxy-2-(methylsulfanyl)tetrahydro-2H-pyran-3-ylhexadecanoathydrochlorid; Clindamycin Hydrochloride Palmitate

物化性质

• 沸点: 767.4ºC at 760 mmHg
• 熔点: 141-143ºC
• 分子式: C₃₄H₆₄Cl₂N₂O₆S
• 分子量: 699.853
• 闪点: 417.9ºC
• 精确质量: 698.386230
• PSA: 133.63000
• LogP: 7.55250
• 蒸汽压: 3.44E-27mmHg at 25°C
• 储存条件: -20°C

生物活性

• 描述: Clindamycin palmitate hydrochloride 是克林霉素和棕榈酸酯的水溶性盐酸盐,是一种抗菌药物。Clindamycin palmitate hydrochloride 在体外是无活性的,快速体内水解可以将该化合物转化为抗菌活性克林霉素。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Bharathi Ch, et al. Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride. J Pharm Biomed Anal. 2008 Dec 1;48(4):1211-8.