3056-18-6

• 常用中文名：9-[2,3,5-三-O-乙酰基-β-D-呋喃核糖基] -2,6-二氯
• 常用英文名：9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE
• CAS号：3056-18-6
• 分子式：C₁₆H₁₆Cl₂N₄O₇
• 分子量：447.2
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2017-12-11 02:35:49
• 更新时间：2026-07-14 22:17:40
• 2,6-二氯-2',3',5'-三乙酰基嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 9-[2,3,5-三-O-乙酰基-β-D-呋喃核糖基] -2,6-二氯
• 英文名: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,6-dichloropurin-9-yl)oxolan-2-yl]methyl acetate
• 中文别名: 2,6-二氯-2,3,5-三乙酰嘌呤核苷; 2,6-二氯-9Β-(2',3',5'-TRI-O-乙酰基)-D-呋喃核糖嘌呤; 2,6-二氯嘌呤-2',3',5'-三乙酰; 2,3,5-三乙酰-2,6-二氯嘌呤核苷; 2-氯腺苷杂质B对照品 (2,6-二氯-9-(2', 3',5'-三-0-乙酰基- Β-D-呋喃核糖基)嘌呤); (2R,3R,4R,5R)-2-(乙酰氧基甲基)-5-(2,6-二氯-9H-嘌呤-9-基)四氢呋喃-3,4-二乙酸二酯; 2,6-二氯-9-(2',3',5'-三-O-乙酰基-BD-呋喃核糖基)嘌呤(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; 9-[2,3,5-三-O-乙酰-BETA-D-呋喃核糖基]-2,6-二氯嘌呤; 2,6-二氯-9-(2,3,5-三-O-乙酰基-BETA-D-呋喃核糖基)-9H-嘌呤; 2,6-二氯-2',3',5'-三乙酰基嘌呤核糖苷; 2,6-二氯-9-(2,3,5-三-O-乙酰基-beta-D-呋喃核糖基)-9H-嘌呤; 2,3,4三乙酰基-2,6二氯嘌呤核苷; 2,6-二氯-9-(2',3',5'-三-O-乙酰基-BD-呋喃核糖基)嘌呤; 2,6-二氯-9-(2',3',5'-三-O-乙酰基-ΒD-呋喃核糖基)嘌呤; 2,6-二氯-9-(2',3',5'-三-O-乙酰基-Β-D-呋喃核糖基)嘌呤; 9-[2,3,5-三-O-乙酰基-Β-D-呋喃核糖基] -2,6-二氯; 2,3,5-三乙酰基-2,6二氯嘌呤; 2,6-二氯-9-(2',3',5'-三-O-乙酰-Β-D-呋喃核糖基)嘌呤; 2,3,三乙酰基-2,6二氯嘌呤核苷; 2-氯腺苷杂质B; 9- '2,3,5-三-O-乙酰基-Β-D-呋喃核糖基 -2,6-二氯; 瑞加德松杂质42
• 英文别名: [4-acetyloxy-5-(acetyloxymethyl)-2-(2,6-dichloropurin-9-yl)oxolan-3-yl] ethanoate; 9H-Purine, 2,6-dichloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl); 9-[2,3,5-TRI-O-ACETYL-SS-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE; 2,6-Dichloro-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine; [3,4-BIS(ACETYLOXY)-5-(2,6-DICHLOROPURIN-9-YL)OXOLAN-2-YL]METHYL ACETATE; 2,6-DCl-2′,3′,5′,-TAc-PuR; 2,6-Dichloro-9-(2′,3′,5′-tri-O-acetyl-β-D-ribofuranosyl)purine; 9-[2,3,5-tri-O-acetyl-D-ribofuranosyl]-2,6-dichloropurine; [3,4-Bis(acetyloxy)-5-(2,6-dichloro-9H-purin-9-yl)oxolan-2-yl]methyl acetate; BINO-004; 2,6-Dichloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine; 2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl acetate; 2,6-dichloro-9-(2,3,5-tri-O-acetylpentofuranosyl)-9H-purine; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; [4-acetyloxy-5-(acetyloxymethyl)-2-(2,6-dichloropurin-9-yl)oxolan-3-yl] acetate; 9H-Purine,2,6-dichloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl); Regadenoson Impurity 42; 2,6-DICHLORO-9-(2,3,5-TRI-O-ACETYL-B-D-RIBOFURANOSYL)-9H-PURINE; acetic acid [4-acetoxy-5-(acetoxymethyl)-2-(2,6-dichloropurin-9-yl)tetrahydrofuran-3-yl] ester; 2,6-Dichloro-2',3',5'-triacetyl-purineriboside; 2',3',5'-Tri-O-Acetyl-2,6-Dichloropurine; [3,4-diacetyloxy-5-(2,6-dichloropurin-9-yl)oxolan-2-yl]methyl acetate; 2-Chloroadenosine impurity B; 2,6-Dichloro-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine; 2,6-Dichloro-2',3',5'-triacetyl-purine riboside

物化性质

• 密度: 1.69g/cm3
• 沸点: 555.3ºC at 760mmHg
• 分子式: C₁₆H₁₆Cl₂N₄O₇
• 分子量: 447.2
• 闪点: 289.6ºC
• 精确质量: 446.0396043
• PSA: 131.73000
• LogP: 1.45700
• 折射率: 1.671
• 储存条件: 2-8℃，惰性气体保存

生物活性

• 描述: 2,6-二氯-2',3',5'-三乙酰基嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

安全

• 危害码 (欧洲): Xn
• 海关编码: 2934999090

合成路线

16321-99-6 ~86% 3056-18-6

文献：Francom, Paula; Robins, Morris J. Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 666 - 669

5451-40-1 13035-61-5 ~84% 3056-18-6

文献：Qu, Guirong; Liu, Qibin Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 1 p. 196 - 197

79999-38-5 ~75% 3056-18-6

文献：Robins; Uznanski Canadian Journal of Chemistry, 1981 , vol. 59, # 17 p. 2601 - 2607

118-00-3 ~% 3056-18-6

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 85 - 87

6979-94-8 ~% 3056-18-6

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 85 - 87

16321-99-6 ~70% 5987-73-5 3056-18-6 40896-58-0

文献：Journal of Organic Chemistry, , vol. 68, # 2 p. 666 - 669

5383-06-2 ~% 3056-18-6

文献：Canadian Journal of Chemistry, , vol. 59, # 17 p. 2601 - 2607

79999-37-4 ~% 3056-18-6

文献：Canadian Journal of Chemistry, , vol. 59, # 17 p. 2601 - 2607

58-61-7 ~% 3056-18-6

文献：Canadian Journal of Chemistry, , vol. 59, # 17 p. 2601 - 2607

上下游产品

上游产品  9
16321-99-6 5451-40-1 13035-61-5 79999-38-5
118-00-3 6979-94-8 5383-06-2 79999-37-4
58-61-7
下游产品  5
36396-99-3 37739-05-2 41552-82-3 15763-11-8
146-77-0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%