9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE

Modify Date: 2024-01-09 12:39:03

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure
9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE structure
Common Name 9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE
CAS Number 3056-18-6 Molecular Weight 433.20
Density 1.69g/cm3 Boiling Point 555.3ºC at 760mmHg
Molecular Formula C15H14Cl2N4O7 Melting Point N/A
MSDS N/A Flash Point 289.6ºC

 Use of 9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE


2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,6-dichloropurin-9-yl)oxolan-2-yl]methyl acetate
Synonym More Synonyms

  Biological Activity

Description 2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.69g/cm3
Boiling Point 555.3ºC at 760mmHg
Molecular Formula C15H14Cl2N4O7
Molecular Weight 433.20
Flash Point 289.6ºC
Exact Mass 446.04000
PSA 131.73000
LogP 1.45700
Index of Refraction 1.671

 Safety Information

Hazard Codes Xn
HS Code 2934999090

 Synthetic Route

~86%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Francom, Paula; Robins, Morris J. Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 666 - 669

~84%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Qu, Guirong; Liu, Qibin Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 1 p. 196 - 197

~75%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Robins; Uznanski Canadian Journal of Chemistry, 1981 , vol. 59, # 17 p. 2601 - 2607

~%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 85 - 87

~%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 85 - 87

~70%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Journal of Organic Chemistry, , vol. 68, # 2 p. 666 - 669

~%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Canadian Journal of Chemistry, , vol. 59, # 17 p. 2601 - 2607

~%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Canadian Journal of Chemistry, , vol. 59, # 17 p. 2601 - 2607

~%

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE Structure

9-[2,3,5-TRI-O-...

CAS#:3056-18-6

Literature: Canadian Journal of Chemistry, , vol. 59, # 17 p. 2601 - 2607

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE
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