中文名 | 阿格列汀 |
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英文名 | alogliptin |
中文别名 | 阿洛利停 |
英文别名 |
ALOGLIPTIN(ALOGLIPTINE,ALOGLIPTINA)
2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile Alogliptin UNII-JHC049LO86 2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrile Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]- 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile alogliptina |
描述 | Alogliptin(SYR-322)是高活性DPP4选择性抑制剂,IC50<10 nM,比对DPP8和DPP9的抑制性高10000倍以上。 |
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相关类别 | |
参考文献 |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 519.2±60.0 °C at 760 mmHg |
分子式 | C18H21N5O2 |
分子量 | 339.392 |
闪点 | 267.8±32.9 °C |
精确质量 | 339.169525 |
PSA | 97.05000 |
LogP | 1.84 |
蒸汽压 | 0.0±1.4 mmHg at 25°C |
折射率 | 1.660 |
储存条件 | 室温,干燥,密封 |
~% 850649-61-5 |
文献:Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300 |
~% 850649-61-5 |
文献:Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300 |