119673-08-4

• 常用中文名：贝卡特林
• 常用英文名：Becatecarin
• CAS号：119673-08-4
• 分子式：C₃₃H₃₄Cl₂N₄O₇
• 分子量：669.552
• 相关类别： 信号通路 细胞周期/DNA损伤 拓扑异构酶
• 发布时间：2016-11-29 13:02:38
• 更新时间：2024-01-10 21:09:03
• Becatecarin是一种具有抗肿瘤作用的rebeccamycin类似物。Becatecarin插入DNA并抑制拓扑异构酶I/II的催化活性。

名称

• 中文名: 贝卡特林
• 英文名: Becatecarin
• 英文别名: 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-; Becatecarin; 1,11-Dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione; 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12-(4-O-methyl-β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-; 1,11-dichloro-6-(2-(diethylamino)ethyl)-12-((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 848.8±65.0 °C at 760 mmHg
• 分子式: C₃₃H₃₄Cl₂N₄O₇
• 分子量: 669.552
• 闪点: 467.2±34.3 °C
• 精确质量: 668.180481
• PSA: 142.18000
• LogP: 7.17
• 蒸汽压: 0.0±3.3 mmHg at 25°C
• 折射率: 1.739

生物活性

• 描述: Becatecarin是一种具有抗肿瘤作用的rebeccamycin类似物。Becatecarin插入DNA并抑制拓扑异构酶I/II的催化活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
• 参考文献:

  [1]. Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266.

  [2]. Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583.