174022-42-5

• 常用中文名：贝韦立马
• 常用英文名：Bevirimat
• CAS号：174022-42-5
• 分子式：C₃₆H₅₆O₆
• 分子量：584.826
• 相关类别： 信号通路 抗感染 HIV
• 发布时间：2018-07-20 12:50:56
• 更新时间：2025-08-25 18:43:44
• Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。

名称

• 中文名: 贝韦立马
• 英文名: bevirimat
• 英文别名: DSB; UNII-S125DW66N8; 3-O-(3',3'-dimethylsuccinyl)betulinic acid; YK FH312; YK-FH312; PA-457; BVM; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; Bevirimat; Butanedioic acid, 2,2-dimethyl-, 4-[(3β)-28-hydroxy-28-oxolup-20(29)-en-3-yl] ester; (3β)-3-[(3-Carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 662.7±40.0 °C at 760 mmHg
• 分子式: C₃₆H₅₆O₆
• 分子量: 584.826
• 闪点: 197.7±20.8 °C
• 精确质量: 584.407715
• PSA: 100.90000
• LogP: 10.15
• 蒸汽压: 0.0±4.3 mmHg at 25°C
• 折射率: 1.548
• 储存条件: -20°C

生物活性

• 描述: Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81.

  [2]. Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72.

  [3]. Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.

合成路线

911140-87-9 ~69% 174022-42-5

文献：Krasutsky, Pavel A.; Munshi, Kalyan Patent: US2009/131714 A1, 2009 ; Location in patent: Page/Page column 8 ;

472-15-1 ~72% 174022-42-5

文献：Biotech Research Labs, Inc.; University of North Carolina at Chapel Hill Patent: US5679828 A1, 1997 ;

1189176-34-8 472-15-1 ~71% 174022-42-5

文献：REGENTS OF THE UNIVERSITY OF MINNESOTA Patent: WO2006/105356 A2, 2006 ; Location in patent: Page/Page column 27-28 ;

17347-61-4 472-15-1 ~5% 174022-42-5

文献：Haavikko, Raisa; Nasereddin, Abedelmajeed; Sacerdoti-Sierra, Nina; Kopelyanskiy, Dmitry; Alakurtti, Sami; Tikka, Mari; Jaffe, Charles L.; Yli-Kauhaluoma, Jari MedChemComm, 2014 , vol. 5, # 4 p. 445 - 451

473-98-3 ~% 174022-42-5

文献：Haavikko, Raisa; Nasereddin, Abedelmajeed; Sacerdoti-Sierra, Nina; Kopelyanskiy, Dmitry; Alakurtti, Sami; Tikka, Mari; Jaffe, Charles L.; Yli-Kauhaluoma, Jari MedChemComm, 2014 , vol. 5, # 4 p. 445 - 451

4481-62-3 ~% 174022-42-5

文献：Haavikko, Raisa; Nasereddin, Abedelmajeed; Sacerdoti-Sierra, Nina; Kopelyanskiy, Dmitry; Alakurtti, Sami; Tikka, Mari; Jaffe, Charles L.; Yli-Kauhaluoma, Jari MedChemComm, 2014 , vol. 5, # 4 p. 445 - 451