贝韦立马

更新时间：2024-01-02 12:54:02

贝韦立马结构式	常用名	贝韦立马	英文名	Bevirimat
	CAS号	174022-42-5	分子量	584.826
	密度	1.1±0.1 g/cm3	沸点	662.7±40.0 °C at 760 mmHg
	分子式	C₃₆H₅₆O₆	熔点	N/A
	MSDS	N/A	闪点	197.7±20.8 °C

贝韦立马用途

Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。

中文名	贝韦立马
英文名	bevirimat
英文别名	更多

描述	Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。
相关类别	信号通路 >> 抗感染 >> HIV 研究领域 >> 感染天然产物 >> 萜类化合物和糖苷
参考文献	[1]. Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81. [2]. Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72. [3]. Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.

描述

Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。

相关类别

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

天然产物 >> 萜类化合物和糖苷

参考文献

[1]. Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81.

[2]. Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72.

[3]. Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.

密度	1.1±0.1 g/cm3
沸点	662.7±40.0 °C at 760 mmHg
分子式	C₃₆H₅₆O₆
分子量	584.826
闪点	197.7±20.8 °C
精确质量	584.407715
PSA	100.90000
LogP	10.15
蒸汽压	0.0±4.3 mmHg at 25°C
折射率	1.548
储存条件	-20°C

(3β)-3-[4-carbo...

911140-87-9

~69%

贝韦立马

174022-42-5

文献：Krasutsky, Pavel A.; Munshi, Kalyan Patent: US2009/131714 A1, 2009 ; Location in patent: Page/Page column 8 ;

白桦脂酸

472-15-1

~72%

贝韦立马

174022-42-5

文献：Biotech Research Labs, Inc.; University of North Carolina at Chapel Hill Patent: US5679828 A1, 1997 ;

4-chloro-2,2-di...

1189176-34-8

白桦脂酸

472-15-1

~71%

贝韦立马

174022-42-5

文献：REGENTS OF THE UNIVERSITY OF MINNESOTA Patent: WO2006/105356 A2, 2006 ; Location in patent: Page/Page column 27-28 ;

2,2-二甲基琥珀酸酐

17347-61-4

白桦脂酸

472-15-1

~5%

贝韦立马

174022-42-5

文献：Haavikko, Raisa; Nasereddin, Abedelmajeed; Sacerdoti-Sierra, Nina; Kopelyanskiy, Dmitry; Alakurtti, Sami; Tikka, Mari; Jaffe, Charles L.; Yli-Kauhaluoma, Jari MedChemComm, 2014 , vol. 5, # 4 p. 445 - 451

白桦脂醇；桦木醇

473-98-3

贝韦立马

174022-42-5

路路通酸

4481-62-3

贝韦立马

174022-42-5

DSB

UNII-S125DW66N8

3-O-(3',3'-dimethylsuccinyl)betulinic acid

YK FH312

YK-FH312

PA-457

BVM

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Bevirimat

Butanedioic acid, 2,2-dimethyl-, 4-[(3β)-28-hydroxy-28-oxolup-20(29)-en-3-yl] ester

(3β)-3-[(3-Carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid