贝韦立马

• 常用名: 贝韦立马
• 英文名: Bevirimat
• CAS号: 174022-42-5
• 分子量: 584.826
• 密度: 1.1±0.1 g/cm3
• 沸点: 662.7±40.0 °C at 760 mmHg
• 分子式: C₃₆H₅₆O₆
• 熔点: N/A
• 闪点: 197.7±20.8 °C

贝韦立马用途

Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。

贝韦立马名称

• 中文名: 贝韦立马
• 英文名: bevirimat

贝韦立马生物活性

• 描述: Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81.

  [2]. Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72.

  [3]. Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.

贝韦立马物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 662.7±40.0 °C at 760 mmHg
• 分子式: C₃₆H₅₆O₆
• 分子量: 584.826
• 闪点: 197.7±20.8 °C
• 精确质量: 584.407715
• PSA: 100.90000
• LogP: 10.15
• InChIKey: YJEJKUQEXFSVCJ-WRFMNRASSA-N
• SMILES: C=C(C)C1CCC2(C(=O)O)CCC3(C)C(CCC4C5(C)CCC(OC(=O)CC(C)(C)C(=O)O)C(C)(C)C5CCC43C)C12
• 蒸汽压: 0.0±4.3 mmHg at 25°C
• 折射率: 1.548
• 储存条件: -20°C

贝韦立马靶点实验

查看更多实验

实验名称：Antiviral activity against wild type HIV1 infected in human HeLa cells assessed as de... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1654158

实验名称：Antiviral activity against HIV1 harboring capsid I201V mutant protein infected in hum... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1654289

实验名称：Antiviral activity against HIV1 harboring spacer peptide A1V mutant protein infected ... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1654290

实验名称：Antiviral activity against HIV1 HXB2 harboring SP1 V7A/T8N mutant gene relative to wi... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1662094

实验名称：Antiviral activity against HIV1 HXB2 harboring SP1 Q6H /V7A/T8delta mutant gene relat... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1662095

实验名称：Antiviral activity against HIV 来源：ChEMBL 靶标：Human immunodeficiency virus External Id：CHEMBL1024115

实验名称：Antiviral activity against HIV1 HXB2 harboring SP1 Q6H /V7A/T8N mutant gene relative ... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1662096

实验名称：Antiviral activity against 0.001 MOI bevirimat-resistant Human immunodeficiency virus... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL2327723

实验名称：Cytotoxicity against human MT4 cells for 4 days 来源：ChEMBL 靶标：MT4 External Id：CHEMBL2327722

实验名称：Antiviral activity against 0.001 MOI wild type Human immunodeficiency virus 1 NL4-3 i... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL2327724

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贝韦立马英文别名

• DSB
• UNII-S125DW66N8
• 3-O-(3',3'-dimethylsuccinyl)betulinic acid
• YK FH312
• YK-FH312
• PA-457
• BVM
• (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
• Bevirimat
• Butanedioic acid, 2,2-dimethyl-, 4-[(3β)-28-hydroxy-28-oxolup-20(29)-en-3-yl] ester
• (3β)-3-[(3-Carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid