68112-21-0

• 常用中文名：抑弹朊酶素
• 常用英文名：Elasnin
• CAS号：68112-21-0
• 分子式：C₂₄H₄₀O₄
• 分子量：392.57
• 相关类别： 信号通路 代谢酶/蛋白酶 弹性蛋白酶
• 发布时间：2018-06-11 19:04:10
• 更新时间：2026-07-02 12:48:28
• Elasnin是一种选择性粒细胞弹性蛋白酶抑制剂。Elasnin对胰腺弹性蛋白酶、胰蛋白酶、糜蛋白酶、嗜热菌蛋白酶和木瓜蛋白酶几乎无效[1]。

名称

• 中文名: 抑弹朊酶素
• 英文名: 3,5-dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)pyran-2-one
• 中文别名: 3,5-二丁基-6-(1-丁基-2-氧代庚基)-4-羟基-2H-吡喃-2-酮
• 英文别名: 3,5-Dibutyl-6-(1-butyl-2-oxohtyl)-4-hydroxy-2H-pyran-2-one; elasnin; 2H-Pyran-2-one, 3,5-dibutyl-6-(1-butyl-2-oxohtyl)-4-hydroxy; 3,5-Dibutyl-4-hydroxy-6-(2-oxo-1-butylhtyl)-2H-pyran-2-one; 2H-Pyran-2-one, 3,5-dibutyl-6-(1-butyl-2-oxohtyl)-4-hydroxy- (9CI)

物化性质

• 密度: 1.001g/cm3
• 沸点: 521ºC at 760 mmHg
• 分子式: C₂₄H₄₀O₄
• 分子量: 392.57
• 闪点: 166.6ºC
• 精确质量: 392.29300
• PSA: 67.51000
• LogP: 6.45380
• 折射率: 1.491

生物活性

• 描述: Elasnin是一种选择性粒细胞弹性蛋白酶抑制剂。Elasnin对胰腺弹性蛋白酶、胰蛋白酶、糜蛋白酶、嗜热菌蛋白酶和木瓜蛋白酶几乎无效[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 弹性蛋白酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. S Omura, et al. Elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. Biochem Biophys Res Commun. 1978 Jul 28;83(2):704-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ0509600 CHEMICAL NAME : 2H-Pyran-2-one, 3,5-dibutyl-6-(1-butyl-2-oxoheptyl)-4-hydroxy- CAS REGISTRY NUMBER : 68112-21-0 BEILSTEIN REFERENCE NO. : 1265379 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C24-H40-O4 MOLECULAR WEIGHT : 392.64 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1116,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 290 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1116,1978

合成路线

73907-88-7 ~66% 68112-21-0

文献：Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

73891-54-0 ~92% 68112-21-0

文献：Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

74583-81-6 ~% 68112-21-0

文献：Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

74583-82-7 ~% 68112-21-0

文献：Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

60988-34-3 ~% 68112-21-0

文献：Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

74583-78-1 ~% 68112-21-0

文献：Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

65837-08-3 ~% 68112-21-0

文献：Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

99903-27-2 ~% 68112-21-0

文献：Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270

74583-83-8 ~% 68112-21-0

文献：Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

上下游产品

上游产品  6
73891-54-0 74583-81-6 74583-82-7 60988-34-3
74583-78-1 65837-08-3
下游产品  0