163521-12-8

• 常用中文名：维拉佐酮
• 常用英文名：Vilazodone
• CAS号：163521-12-8
• 分子式：C₂₆H₂₇N₅O₂
• 分子量：441.52
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-06-08 17:44:52
• 更新时间：2026-07-07 23:56:17
• Vilazodone(EMD 68843; SB 659746A)是五羟色胺重吸收抑制剂(SSRI)和5-HT1A受体部分激动剂。

名称

• 中文名: 维拉佐酮
• 英文名: vilazodone
• 中文别名: 维拉佐酮(SSRI抑制剂); 盐酸维拉佐酮C10; 维拉唑酮; 5-(4-(4-(5-氰基-1H-吲哚-3-基)丁基)哌嗪-1-基)苯并呋喃-2-甲酰胺; 维拉佐酮/163-8; 维拉佐酮盐酸盐; 维拉佐酮(游离碱); 维拉佐酮,10 MM DMSO 溶液; 维拉佐酮|||SB659746A|||EMD; 甲基-2H-异吲哚-1,3-二酮; 盐酸维拉佐酮系列/维拉佐酮; 盐酸维拉佐酮; 维拉唑酮杂质
• 英文别名: CleEyes; Vilazodonei with low price CAS NO.163-8; 5‐{4‐[4‐(5‐Cyano‐1H‐indol‐3‐yl)‐butyl]‐1‐piperazinyl}‐2‐ benzofurancboxamide; 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-cboxamide; Vilozodone; Vilazodone [inn]; 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide; VilazodoneQ: What is Vilazodone Q: What is the CAS Number of Vilazodone Q: What is the storage condition of Vilazodone Q: What e the applications of Vilazodone; Vilazodone 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-cboxamide; 5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-1-benzofuran-2-carboxamide; VILAZODONE; Vilazodone, >=; VILAZODONE API; Velazolone; 5-(4-(4-(5-Cyanoindol-3-yl)butyl)-1-piperazinyl)-2-benzofurancboxamide; 5-(4-(4-(5-cyano-1H-indol-3-yl) butyl) piperazin-1- yl) benzofuran-2-cboxaMide hydrochloride; 2-BenzofurancboxaMide,5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]; VIIBRYD; 5-(4-[4-(5-CYANO-1H-INDOL-3-YL)BUTYL]PIPERAZIN-1-YL)BENZOFURAN-2-CBOXAMIDE; SB659746A|||EMD; All Cle; UNII-S239O2OOV3; AK-Con; Velazolone hydrochloride; Vilazodone, 10 mM in DMSO; VILAZODONE //BP; Vilazodone-d6; 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-cboxamide; Viibryd; 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide; Vilazodonei; Vilazodone HCL; Verazodone hydrochloride; 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-cboxamide; 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide; VILAZODONE 163-8

物化性质

• 密度: 1.34 g/cm3
• 沸点: 745.1ºC at 760 mmHg
• 熔点: 203-205ºC
• 分子式: C₂₆H₂₇N₅O₂
• 分子量: 441.52
• PSA: 102.29000
• LogP: 5.53478
• 外观性状: 淡黄色固体
• 储存条件: -20°C

生物活性

• 描述: Vilazodone(EMD 68843; SB 659746A)是五羟色胺重吸收抑制剂(SSRI)和5-HT1A受体部分激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31.

  [2]. Citrome L. Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J C

  [3]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28(1):27-39.

  [4]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009

  [5]. Thomas L. Schwartz Vilazodone: a brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor Therapeutic Advances in Psychopharmacology June 2011 vol. 1 no. 3 81-87

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