35597-43-4

• 常用中文名：双丙氨膦
• 常用英文名：bilanafos
• CAS号：35597-43-4
• 分子式：C₁₁H₂₂N₃O₆P
• 分子量：323.28300
• 相关类别： 原料药 抗生素类药物 其它抗生素类药
• 发布时间：2018-08-14 13:43:10
• 更新时间：2026-07-02 15:55:53
• Bilanafos 是一种由 scopscopius Streptomyces 或 Streptomyces viridochromegenes 代谢产生的天然有机膦三肽抗生素。Bialaphos 对革兰氏阴性菌和阳性菌以及一些植物真菌病害具有抗菌活性。

名称

• 中文名: 双丙氨膦
• 英文名: bilanafos
• 中文别名: 双丙氨酰膦
• 英文别名: 2-Amino-4-(methylphosphino)butyrylalanylalanine; L-2-Amino-4-[(4-hydroxy)(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine sodium salt; BIALOPHOS; Antibiotic SF 1293; L-Alanine,4-(hydroxymethylphosphinyl)-L-2-aminobutanoyl-L-alanyl; Phosphinothricylalanylalanine; (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine; gamma-(hydroxymethylphosphinyl)-l-alpha-aminobutyryl-l-alanyl-l-alanin; BIALAPHOS; γ- -L-α-aminobutyryl-L-alanyl-L-alanine; L-2-AMINO-4-[(HYDROXY)(METHYL)PHOSPHINOYL]BUTYRYL-L-ALANYL-L-ALANINE SODIUM SALT; N-{(2S)-2-amino-4-[hydroxy(Methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine; (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine; TIANFUCHEM- 35-4-High purity BIALAPHOS in stock; SF-1293; Bilanafos [ISO]; gamma-(hydroxymethylphosphinyl)-l-alpha-aminobutyryl-l-alanyl-l-alanine; Herby; L-Alanine, (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl; bialaphos; BIALAPHOS //BP; γ- -D-α-aminobutyryl-L-alanyl-L-alanine; Bialaphos; Bilanafos; 4-(Methylhydroxyphosphinyl)-L-Abu-L-Ala-L-Ala-OH; acide diprogulique; (2S)-2-[[(2S)-2-[[(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl]amino]propanoyl]amino]propanoic acid; Phosphinothricyclalanylalanine sodium; 4-(hydroxymethylphosphinyl)-l-2-aminobutanoyl-l-alanyl-l-alanin; antibioticsf1293; C06457

物化性质

• 密度: 1.33g/cm3
• 沸点: 793.2ºC at 760 mmHg
• 熔点: 159-161ºC
• 分子式: C₁₁H₂₂N₃O₆P
• 分子量: 323.28300
• 闪点: 433.5ºC
• 精确质量: 323.12500
• PSA: 182.29000
• 折射率: 1.517
• 储存条件: Store dry at -4

生物活性

• 描述: Bilanafos 是一种由 scopscopius Streptomyces 或 Streptomyces viridochromegenes 代谢产生的天然有机膦三肽抗生素。Bialaphos 对革兰氏阴性菌和阳性菌以及一些植物真菌病害具有抗菌活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Takeshi Murakami, et al.The bialaphos biosynthetic genes ofStreptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster. Molecular and General Genetics MGG volume 205, pages42–53 (1986)

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AY6826000 CHEMICAL NAME : L-Alanine, gamma-(hydroxymethylphosphinyl)-L-alpha-aminobutyryl- L-alanyl- CAS REGISTRY NUMBER : 35597-43-4 LAST UPDATED : 199604 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C11-H22-N3-O6-P MOLECULAR WEIGHT : 323.33 WISWESSER LINE NOTATION : QVY1&MVY1&MVYZ2PHO&1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),223,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),223,1980

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 26-36

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