上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：哌库溴铵
纯度：98.0%
规格：10mg/1g/1g/1g
联系人：阿拉丁

2881459338 复制
联系电话：400-620-6333

湖北鑫红利化工有限公司
湖北省省直辖县级行政单位天门市
产品名：哌库溴铵
纯度：99.0%
规格：500g/1kg/25kg/200kg
联系人：魏女士

1400828899 复制

18871490254 复制
联系电话：18871490254

上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：哌库溴铵
纯度：98.0%
规格：
联系人：小陈

454578593 复制

18916513247 复制
联系电话：18916513247

查看所有供应商和价格请点击：

52212-02-9生产厂家

52212-02-9价格

52212-02-9

52212-02-9结构式

常用中文名：哌库溴铵
常用英文名：4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide
CAS号：52212-02-9
分子式：C₃₅H₆₂Br₂N₄O₄
分子量：762.69900
相关类别：原料药 Anesthetic Agents 骨骼肌松弛药
发布时间：2018-06-14 00:35:35
更新时间：2026-07-02 09:11:02
Pipecuronium bromide 是一种有效的长效非去极化甾体神经肌肉阻滞剂 (NMBA),是一种双季铵化合物。Pipecuronium bromide 是一种功能强大的竞争性 nAChR 拮抗剂,Kd 为 3.06 μM。

化源商城直购

中文名	哌库溴铵
英文名	4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide
中文别名	哌库溴铵/52-9 4,4'-[(2Β,3Α,5Α,16Β,17Β)-3,17-双(乙酰氧基)雄甾烷-2,16-亚基]双(1,1-二甲基哌嗪锚)二溴化物阿端哌可松溴化吡哌考尼
英文别名	4,4'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetoxy)androstane-2,16-diyl]bis[1,1-dimethylpiperazinium] dibromide 4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide duan (tn) Pipecuronium Pipecuronium bromide (usan/inn) Pipecuronium bromide //BP Arduan (tn) pipecuronium bromide Pipecuroniumbromid Pipecuriurn Brmnide PipecuroniuM BroMide(RGH-1106) duan Piperazinium, 4,4'-[(2b,3a,5a,16b,17b.)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1,1-dimethyl-, bromide (1:2) PIPECURINIUM BROMIDE dtm Muscle relaxant Pipecuronium bromide /In stock CAS NO.52-9 CAS NO.52-9 WGBNBQWFBQRF-UHFFFAOYSA-N PIPECURIUM BROMIDE Ardtm RGH-1106 Arduan 4，4’-[(2β，3α，5α，16β，17β)-3，17-Bis(acetoxy)andrc~tane-2，16-diyl]bis(1，1-dimethylpiperazinium)dibromide D00764 acetic acid [17-acetyloxy-2,16-bis(4,4-dimethyl-1-piperazin-4-iumyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester dibromide Androstane, piperazinium deriv EINECS 257-740-4 [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-2,16-bis(4,4-dimethyl-2,3,5,6-tetrahydropyrazin-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide Pipecuronium (Pipecurium)Bromide

描述	Pipecuronium bromide 是一种有效的长效非去极化甾体神经肌肉阻滞剂 (NMBA),是一种双季铵化合物。Pipecuronium bromide 是一种功能强大的竞争性 nAChR 拮抗剂,Kd 为 3.06 μM。
相关类别	信号通路 >> 跨膜转运 >> 胆碱受体信号通路 >> 神经信号通路 >> 胆碱受体研究领域 >> 神经疾病
靶点	nAChR[4][5]
体外研究	糖胺对溴化哌库宁有很高的亲和力。由于哌库溴铵的效力是罗库溴铵的6至7倍,因此实现相对阻断所需的分子比罗库溴铵少[1]。
体内研究	平均ED95为0.045mg/kg(0.035-0.059mg/kg),起效时间为2-6.3min,取决于剂量和背景麻醉。哌库溴铵不释放组胺,即使在3×ED95剂量下也无心血管副作用,过敏反应似乎不存在问题〔2〕。在离体大鼠膈肌实验中,羧甲基化γ-环糊精显示了哌库溴铵诱导的神经肌肉阻滞的有效和完全逆转[3]。
参考文献	[1]. Tassonyi E, et al. Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic: A Randomized Trial. Anesth Analg. 2015 Aug;121(2):373-80. [2]. Tassonyi E, et al. Reversal of Deep Pipecuronium-Induced Neuromuscular Block With Moderate Versus Standard Dose of Sugammadex: A Randomized, Double-Blind, Noninferiority Trial. Anesth Analg. 2018 Dec;127(6):1344-1350. [3]. Alánt O, et al. First clinical experience with a new neuromuscular blocker pipecurium bromide. Arzneimittelforschung. 1980;30(2a):374-9. [4]. Töröcsik A, et al. Characterization of somatodendritic neuronal nicotinic receptors located on the myenteric plexus. Eur J Pharmacol. 1991 Sep 24;202(3):297-302. [5]. Kárpáti E, et al. Investigation of neuromuscular blocking agents at Richter Ltd. Acta Pharm Hung. 2002;72(1):37-48.

密度	1.329
熔点	262-264ºC
分子式	C₃₅H₆₂Br₂N₄O₄
分子量	762.69900
精确质量	760.31400
PSA	59.08000
储存条件	2-8°C，密封，干燥
更多	1.性状：从二氯甲烷-丙酮结晶。 2.熔点：262-264℃(分解)。 3.比旋光度：[α] _D²³+8.1°(C=1，水)。

毒理学数据:

急性毒性LD₅₀小鼠，大鼠(mg/kg)：29.7，172.6静脉注射；70.6，449.6腹腔注射。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM3170000

CHEMICAL NAME :: Piperazinium, 4,4'-(3,17-dihydroxyandrostan-2,16-diyl)bis(1,1-dimet hyl-, dibromide, diacetate

CAS REGISTRY NUMBER :: 52212-02-9

LAST UPDATED :: 199012

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C35-H62-N4-O4.2Br

MOLECULAR WEIGHT :: 762.83

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 FOV1 OOV1 G- DT6K DNTJ A1 A1& P- DT6K DNTJ A1 A1 &E 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 456 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 173 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70600 ng/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60500 ng/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29700 ng/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55300 ng/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10200 ng/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,346,1980

危害码 (欧洲)	Xi
风险声明 (欧洲)	R36/37/38:Irritating to eyes, respiratory system and skin .
安全声明 (欧洲)	S26-S36
WGK德国	3
RTECS号	GN6820000
海关编码	29322980

74-83-9

52211-99-1

~92%

52212-02-9

文献：Tuba Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 2 A p. 342 - 346

上游产品 1
74-83-9
下游产品 0

5α-雄甾-2-烯-17-酮在硫酸催化下，和乙酸异丙烯酯反应，得化合物(I)，收率80%，熔点96~98℃。
90g化合物(I)溶于500ml苯中，在冷却和搅拌下，于1h内加入92g过苯甲酸在1000ml苯中的溶液，在室温下放置5h。反应液用冰冷却过的氢氧化钠溶液洗，然后水洗，无水硫酸镁干燥。减压浓缩，剩余物用乙醚重结晶，得80g化合物(Ⅱ)，收率81%，熔点182～184℃。
20g化合物(Ⅱ)溶于100ml N-甲基哌嗪和30ml水的混合液，在氮气中回流70h。减压蒸出过量的N-甲基哌嗪，剩余物和2倍量的乙腈混合，沸腾回流数分钟。冷至0℃，过滤析出的白色结晶，真空干燥至恒重，得19g化合物(Ⅲ)，收率63%，熔点199～201℃。
10.6g化合物(Ⅲ)溶于50ml四氢呋喃和50ml甲醇的混合液，加入9g过量的硼氢化钠，搅拌6h。减压蒸出溶剂，剩余物溶于氯仿。先用2%氢氧化钠溶液洗，然后用水洗。干燥后蒸出溶剂，剩余物用氯仿和丙酮混合液重结晶，得9.3g化合物(Ⅳ)，收率91%，熔点264～267℃。
5.8g化合物(Ⅳ)溶于20ml乙酸酐和5ml乙酸的混合液，加入0.5g氯化锌，在室温下搅拌3h。反应液倾人250ml水，于0℃放置。过滤出沉淀，溶于乙醚，用水洗至中性。蒸去溶剂，再用正己烷重结晶，得5g化合物(V)，收率71%，熔点128～130℃。
37.4g化合物(V)和16g溴甲烷溶于1300ml丙酮，在室温下保持30h。过滤析出的结晶，用二氯甲烷和丙酮的混合液来提纯，得48g哌库溴铵，收率92%，熔点262～264℃(分解)。
最后一步反应如下。4g化合物(V)溶于40ml二氯甲烷和20ml硝基甲烷的混合液中，加入9ml溴甲烷。在压力管中于室温下放置2d。过滤除去三甲基化的溴化物副产物。滤液用乙醚稀释，过滤形成的固体，用二氯甲烷和乙醚混合液重结晶，得哌库溴铵。

海关编码	29322980

946312-72-7	946281-84-1
946363-65-1	941885-65-0
946312-76-1	942009-88-3
69464-43-3	941974-46-5
919977-23-4	941915-72-6

52212-02-9

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

本网页内容来自不同专业数据源，如对内容有疑义，欢迎联系service1@chemsrc.com。