135463-81-9

• 常用中文名：考拉西坦
• 常用英文名：coluracetam
• CAS号：135463-81-9
• 分子式：C₁₉H₂₃N₃O₃
• 分子量：341.404
• 相关类别： 原料药 神经系统用药 脑代谢调节药
• 发布时间：2018-05-28 08:00:00
• 更新时间：2026-07-01 16:52:30
• Coluracetam(MKC-231)是新型的胆碱吸收增强剂。

名称

• 中文名: 考拉西坦
• 英文名: N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
• 中文别名: 化合物：Coluracetam; N-(2,3-二甲基-5,6COLURACETAM7,8-四氢呋喃并[2,3-B]喹啉-4-基)-2-(2-氧代吡咯烷-1-基)乙酰胺; 考拉西坦,10 MM DMSO 溶液; 考拉西坦,BCI-540,MKC-231; 化合物:Coluracetam; 可乐西坦; N-(2,3-二甲基-5,6,7,8-四氢呋喃并[2,3-B]喹啉-4-基)-2-(2-氧代吡咯烷-1-基)乙酰胺; N-(2,3-二甲基-5,6,7,8-四氢呋喃并[2,3-b]喹啉-4-基)-2-(2-氧代吡咯烷-1-基)乙酰胺; 呋喃(2,3-B)喹啉-1-吡咯烷乙酰胺衍生物; 考拉西坦 COLURACETAM
• 英文别名: top quality Coluracetam; 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide; COLURACETAM //BP; 1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl); MKC-231; MKC231; MKC; BCI-540; 1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)cbaMoylMethyl]pyrrolidin-2-one; MKC-231;BCI-540; Coluracetam, 10 mM in DMSO; COLURACETAM; coluracetam cas: 135-9; UNII-V6FL6O5GR7; Furo(2,3-b)quinoline-1-pyrrolidineacetamide Deriv; N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro(2,3-b)quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide; COLURACETAM MKC-231 BCI-540; Colurac tam; N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide; Coluracetam, MKC-231; Coluracetam, >=; N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide; Coluracetam [INN]

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 634.1±55.0 °C at 760 mmHg
• 熔点: 225 °C
• 分子式: C₁₉H₂₃N₃O₃
• 分子量: 341.404
• 闪点: 337.3±31.5 °C
• 精确质量: 341.173950
• PSA: 75.44000
• LogP: 3.27
• 外观性状: 固体;White to Almost white powder to crystaline
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.641
• 储存条件: 存放于惰性气体之中;避免空气

生物活性

• 描述: Coluracetam(MKC-231)是新型的胆碱吸收增强剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bessho T, et al. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats. Arzneimittelforschung. 1996 Apr;46(4):369-73.

  [2]. Murai S, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%