67655-94-1

• 常用中文名：N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸
• 常用英文名：AMASTATIN
• CAS号：67655-94-1
• 分子式：C₂₁H₃₈N₄O₈
• 分子量：474.54800
• 发布时间：2018-12-18 11:44:58
• 更新时间：2026-08-03 14:02:58
• Amastatin is a non-toxic inhibitor of aminopeptidase A (Ki = 1 μM) and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.

名称

• 中文名: N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸
• 英文名: amastatin
• 英文别名: Aids-059868; N-[(2S,3R)-3-Amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl-L-valyl-L-asptic acid; N-[N-[N-[(2S,3R)-3-Amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl]-L-valyl]-L-asptic acid; s*))-(s-(r; Amastatin (0.5 mg vial); S-(R*,S*)]-N-[N-[N-(3-Amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl]-L-valyl]-L-asptic acid; amastatin,streptomyces species; N-[(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl]-L-Val-L-Val-L-Asp-OH; L-Asptic acid, N-[(2S,3R)-3-amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl-L-valyl; [(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-L-VALYL-L-VALYL-L-ASPTIC ACID; AMASTATIN, STRTOMYCES SPECIES; (AMINO-2-HYDROXY-5-METHYL-HEXANOYL)-L-VALYL-L-VALYL-L-ASPTIC ACID; (2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL-VAL-VAL-ASP-OH; Antipain (0.5 mg vial); N-[(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-L-VALYL-L-VALYL-L-ASPTIC ACID; l-aspticacid,n-(n-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-l-valyl)-l-valyl); Aids059868; [(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl]-Val-val-Asp

物化性质

• 密度: 1.228g/cm3
• 沸点: 795.1ºC at 760 mmHg
• 分子式: C₂₁H₃₈N₄O₈
• 分子量: 474.54800
• 闪点: 434.7ºC
• 精确质量: 474.26900
• PSA: 208.15000
• LogP: 0.91940
• 折射率: 1.523

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CI9098850 CHEMICAL NAME : L-Aspartic acid, N-(N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl) -L-valyl)-, (S-(R*,S*))- CAS REGISTRY NUMBER : 67655-94-1 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C21-H38-N4-O8 MOLECULAR WEIGHT : 474.63 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,636,1978

安全

• 危害码 (欧洲): Xi

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