26155-31-7

• 常用中文名：酒石酸甲噻嘧啶
• 常用英文名：Morantel tartrate
• CAS号：26155-31-7
• 分子式：C₁₆H₂₂N₂O₆S
• 分子量：370.421
• 相关类别： 原料药 抗寄生虫病药 驱肠虫药
• 发布时间：2018-05-09 08:00:00
• 更新时间：2024-01-10 19:06:57
• Morantel酒石酸是一种广谱驱肠虫药, 效果好, 毒性低。

名称

• 中文名: 酒石酸甲噻嘧啶 水合物
• 英文名: morantel tartrate salt
• 中文别名: 酒石酸甲噻嘧啶
• 英文别名: RUMATEL; trate; morantreltartrate; EINECS 247-481-5; 1,4,5,6-Tetrahydro-1-methyl-2-(2-[3-methyl-2-thienyl]ethenyl)pyrimidine; MORTANELTARTRATE; (2R,3R)-2,3-Dihydroxysuccinic acid - 1-methyl-2-[2-(3-methyl-2-thienyl)vinyl]-1,4,5,6-tetrahydropyrimidine (1:1); MFCD00079449; MORANTEL TARTRATE HYDRATE; Morantel (+)-tartrate salt; banminthii; Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-[2-(3-methyl-2-thienyl)ethenyl]pyrimidine (1:1); Morantel hydrogen tartrate; Morantel tartrate; Morantel (tartrate)

物化性质

• 沸点: 334.6ºC at 760 mmHg
• 分子式: C₁₆H₂₂N₂O₆S
• 分子量: 370.421
• 闪点: 156.1ºC
• 精确质量: 370.119843
• PSA: 158.90000
• LogP: 0.05460
• 外观性状: 白色或淡黄色,结晶粉末
• 蒸汽压: 0.000127mmHg at 25°C
• 储存条件: -20℃

生物活性

• 描述: Morantel酒石酸是一种广谱驱肠虫药, 效果好, 毒性低。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UW0246000 CAS REGISTRY NUMBER : 26155-31-7 LAST UPDATED : 199512 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C12-H16-N2-S.C4-H6-O6 MOLECULAR WEIGHT : 370.46 WISWESSER LINE NOTATION : T6N CN AUTJ B1U1- BT5SJ C1& C1 &QVYQYQVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 926 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Skin and Appendages - hair REFERENCE : AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S323,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S323,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 38800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S323,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature increase REFERENCE : AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S323,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature increase REFERENCE : AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S323,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14850 mg/kg/9D-C TOXIC EFFECTS : Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S323,1992

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H332
• 警示性声明: P261-P301 + P312 + P330
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: UW0246000